Imagination as a fundamental function of the hippocampus.
Imagination as a fundamental function of the hippocampus.
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DOI：
10.1098/rstb.2021.0336
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发表时间：
2022-12-19
影响因子：
6.3
通讯作者：
Kay, Kenneth
中科院分区：
文献类型：
--
作者：
Comrie, Alison E.;Frank, Loren M.;Kay, Kenneth
想象力是一种生物功能，对人类的经验和高级认知至关重要。尽管如此重要，我们仍然不知道想象力是如何在大脑中实现的。对海马体（一种传统上与记忆有关的大脑结构）的大量研究表明，空间调谐神经元的放电模式可以代表空间中先前和即将到来的路径。这项工作通常被解释为标准的观点，海马实现认知能力主要与实际经验，无论是在过去（如回忆，巩固），现在（如空间映射）或未来（如规划）。然而，最近在啮齿动物中的研究发现，海马放电的模式与实际经验的各种替代方案相对应，在许多情况下，没有明显的参考过去，现在或未来。鉴于这些发现，以及其他关于海马体对人类想象力的贡献的发现，我们认为海马体的一个基本功能是产生大量假设的经验和想法。在这种观点下，海马在情景记忆和空间导航中的功能的传统解释可以被理解为更一般的想象系统的特殊应用。这一观点还表明，海马体对认知能力的贡献比以前认为的更广泛。这篇文章是主题问题“思考可能性：机制，个体发育，功能和遗传”的一部分。
Imagination is a biological function that is vital to human experience and advanced cognition. Despite this importance, it remains unknown how imagination is realized in the brain. Substantial research focusing on the hippocampus, a brain structure traditionally linked to memory, indicates that firing patterns in spatially tuned neurons can represent previous and upcoming paths in space. This work has generally been interpreted under standard views that the hippocampus implements cognitive abilities primarily related to actual experience, whether in the past (e.g. recollection, consolidation), present (e.g. spatial mapping) or future (e.g. planning). However, relatively recent findings in rodents identify robust patterns of hippocampal firing corresponding to a variety of alternatives to actual experience, in many cases without overt reference to the past, present or future. Given these findings, and others on hippocampal contributions to human imagination, we suggest that a fundamental function of the hippocampus is to generate a wealth of hypothetical experiences and thoughts. Under this view, traditional accounts of hippocampal function in episodic memory and spatial navigation can be understood as particular applications of a more general system for imagination. This view also suggests that the hippocampus contributes to a wider range of cognitive abilities than previously thought. This article is part of the theme issue ‘Thinking about possibilities: mechanisms, ontogeny, functions and phylogeny’.
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