Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells.
Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells.
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DOI：
10.1080/14686996.2016.1190257
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发表时间：
2016
影响因子：
5.5
通讯作者：
Inoue Y
中科院分区：
文献类型：
--
作者：
Ishihara K;Chen W;Liu Y;Tsukamoto Y;Inoue Y
多功能聚合物纳米粒子是具有广泛生物医学应用潜力的材料。为了在这一研究领域取得进展，必须避免这些纳米颗粒与蛋白质和细胞在生物环境中的不利相互作用，例如通过纳米颗粒表面的处理。基于含有两性离子磷胆碱基团的聚合物构建人工细胞膜结构，可以有效地防止表面的生物反应。此外，某些生物活性分子可以固定在聚合物的表面，以产生足够的亲和力来捕获目标生物分子。此外，无机纳米颗粒在聚合物基质中的包埋显著提高了纳米颗粒的功能性。本文综述了细胞相容性和多功能聚合物纳米颗粒的制备和表征，分析了其荧光功能的效率、人工细胞膜结构的性质以及作为细胞内器件的性能，最后评价了它们在细胞内的化学反应活性和效应。细胞可以摄取聚合物纳米颗粒，嵌入细胞兼容的磷脂聚合物和细胞穿透肽覆盖的量子点。
Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through treatment of the nanoparticle surfaces. Construction of an artificial cell membrane structure based on polymers bearing the zwitterionic phosphorylcholine group can prevent biological reactions at the surface effectively. In addition, certain bioactive molecules can be immobilized on the surface of the polymer to generate enough affinity to capture target biomolecules. Furthermore, entrapment of inorganic nanoparticles inside polymeric matrices enhances the nanoparticle functionality significantly. This review summarizes the preparation and characterization of cytocompatible and multifunctional polymeric nanoparticles; it analyzes the efficiency of their fluorescence function, the nature of the artificial cell membrane structure, and their performance as in-cell devices; and finally, it evaluates both their chemical reactivity and effects in cells. Cells can uptake polymer nanoparticles, embedding quantum dots covered with cytocompatible phospholipid polymers and cell-penetrating peptides.
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影响因子：
3.1
作者：
Breus VV;Pietuch A;Tarantola M;Basché T;Janshoff A
通讯作者：
Janshoff A
DOI：
10.1016/s1468-6996(00)00012-7
发表时间：
2000-01-01
影响因子：
5.5
作者：
Ishihara, K.
通讯作者：
Ishihara, K.
影响因子：
6.2
作者：
Goto, Yusuke;Matsuno, Ryosuke;Ishihara, Kazuhiko
通讯作者：
Ishihara, Kazuhiko
影响因子：
24.2
作者：
Abe, Hideki;Liu, Jia;Ariga, Katsuhiko
通讯作者：
Ariga, Katsuhiko
影响因子：
5.8
作者：
Chen, Weixin;Inoue, Yuuki;Ishihara, Kazuhiko
通讯作者：
Ishihara, Kazuhiko