Silk fibroin-gelatin photo-crosslinked 3D-bioprinted hydrogel with MOF-methylene blue nanoparticles for infected wound healing.
Silk fibroin-gelatin photo-crosslinked 3D-bioprinted hydrogel with MOF-methylene blue nanoparticles for infected wound healing.
复制标题
丝纤维蛋白明星素与MOF-甲基蓝纳米颗粒相结合的3D-Bioprinted水凝胶可用于感染伤口愈合。
DOI：
10.18063/ijb.773
复制
发表时间：
2023
影响因子：
8.4
通讯作者：
Wang, Chen
中科院分区：
文献类型：
--
作者：
Li, Zhuoyuan;Zheng, Ao;Mao, Zhiyuan;Li, Fupeng;Su, Tingshu;Cao, Lingyan;Wang, Wei;Liu, Yang;Wang, Chen
光交联水凝胶（PH）是一个优秀的候选人三维（3D）打印作为伤口敷料，因为它的高效率的交联和注射。在这项研究中，亚甲基蓝（MB）负载UiO-66（Ce）纳米粒子（NPs）的合成，以防止药物的自聚集，并实现有效的抗菌作用的光动力学治疗（PDT）的效果。然后，制备了负载MB@UiO-66（Ce）纳米粒子的光交联丝素/明胶复合水凝胶（MB@UiO-66（Ce）/PH）。阐明了纳米粒子对水凝胶的印刷适性和机械性能的改善。该水凝胶具有良好的生物相容性，并促进成纤维细胞的迁移和增殖。在MB@UiO-66（Ce）NPs的PDT作用下，水凝胶显示出优异的抗菌效果，其随着浓度增加而变得更加明显。体内实验表明，MB@UiO-66（Ce）/PH能无间隙地填充缺损，加快小鼠全层皮肤缺损的修复速度。MB@UiO-66（Ce）/PH具有抗菌性能和促进组织愈合的能力，为制备伤口敷料提供了一种涉及3D生物打印的新策略。
Photo-crosslinked hydrogel (PH) is an outstanding candidate for three-dimensional (3D) printing as a wound dressing because of its high efficiency in crosslinking and injectability. In this study, methylene blue (MB)-loaded UiO-66(Ce) nanoparticles (NPs) were synthesized to prevent drug self-aggregation and achieve the photodynamic therapy (PDT) effect for efficient antibacterial action. Then, a composite photocrosslinked silk fibroin (SF)/gelatin hydrogel loaded with MB@UiO-66(Ce) NPs (MB@UiO-66(Ce)/PH) was fabricated. The printability and the improvement of the mechanical properties of the hydrogel by the NPs were clarified. The hydrogel exhibited good biocompatibility and promoted the migration and proliferation of fibroblasts. With the PDT effect of MB@UiO-66(Ce) NPs, the hydrogel showed an excellent antibacterial effect, which became more pronounced as the concentration increased. In vivo study showed that the MB@UiO-66(Ce)/PH could fill the defects without gaps and accelerate the repair rate of full-thickness skin defects in mice. The MB@UiO-66(Ce)/PH with antibacterial properties and tissue healing-promoting ability provides a new strategy involving 3D bioprinting for preparing wound dressings.
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DOI：
10.1007/978-981-15-3258-0_4
发表时间：
2020-01-01
期刊：
BIOINSPIRED BIOMATERIALS: ADVANCES IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE
影响因子：
--
作者：
Kim, Soon Hee;Kim, Do Yeon;Park, Chan Hum
通讯作者：
Park, Chan Hum
影响因子：
19
作者：
Chen, Qi-Wen;Liu, Xin-Hua;Zhang, Xian-Zheng
通讯作者：
Zhang, Xian-Zheng
DOI：
10.1016/j.jiec.2020.03.034
发表时间：
2020-09-25
影响因子：
6.1
作者：
Lee, Hyunji;Shin, Donghyeok;Hyun, Jinho
通讯作者：
Hyun, Jinho
影响因子：
8.3
作者：
Huang, Kai;Li, Fupeng;Yang, Shengbing
通讯作者：
Yang, Shengbing
影响因子：
4.9
作者：
Augustine R
通讯作者：
Augustine R