Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment.
Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment.
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DOI：
10.1371/journal.pone.0195960
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Katayama I
中科院分区：
文献类型：
--
作者：
Ono E;Murota H;Mori Y;Yoshioka Y;Nomura Y;Munetsugu T;Yokozeki H;Katayama I
汗液中含有维持皮肤稳态所需的活性成分和代谢物。特应性皮炎（AD）引起的汗液成分变化已被报道。为了研究汗液成分对阿尔茨海默病发病机制的影响，我们进行了多方面的评估，包括基于核磁共振波谱的代谢组学分析，并将这些特征与阿尔茨海默病的临床特征联系起来。AD汗液的独特特性是蛋白质、抗微生物肽和葡萄糖浓度的差异。AD患者汗液中的pH、钠和其他盐分水平与健康受试者相当。伴有急性炎症的AD患者的汗液中葡萄糖浓度的升高比健康人或伴有慢性炎症的AD患者的汗液中葡萄糖浓度的升高更为显著。局部葡萄糖应用延迟屏障破坏小鼠经皮失水的恢复。此外，葡萄糖转运蛋白GLUT2在AD患者的汗腺管腔中高表达。伴有慢性炎症的AD患者GLUT2 mRNA表达显著升高，汗液葡萄糖水平接近正常水平。尽管我们的研究样本量小，但我们推测葡萄糖水平升高可能受到AD严重程度和表型的影响。我们希望这篇报道能够为汗液成分对AD临床表现的影响带来新的见解。
Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, and linked these features to clinical features of AD. Distinctive properties of AD sweat are the quite-variation in protein, anti-microbial peptides and glucose concentrations. pH, sodium, and other salt levels in sweat of AD were comparable to that of healthy subjects. Sweat from AD patients with acute inflammation had a more prominent increase in glucose concentration than sweat from healthy individuals or those with AD with chronic inflammation. Topical glucose application delayed recovery of transepidermal water loss in barrier-disrupted mice. Furthermore, the glucose transporter GLUT2 was highly expressed in the lumen of sweat glands from AD patients. AD patients with chronic inflammation had significantly increased GLUT2 mRNA expression and near normal sweat glucose levels. Despite the small sample size in our study, we speculate that the increased glucose levels might be affected by AD severity and phenotype. We hope that this report will bring novel insight into the impact of sweat components on the clinical manifestation of AD.
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