Preexisting hippocampal network dynamics constrain optogenetically induced place fields.
Preexisting hippocampal network dynamics constrain optogenetically induced place fields.
复制标题
DOI：
10.1016/j.neuron.2021.01.011
复制
发表时间：
2021-03-17
期刊：
影响因子：
16.2
通讯作者：
Buzsáki G
中科院分区：
文献类型：
--
作者：
McKenzie S;Huszár R;English DF;Kim K;Christensen F;Yoon E;Buzsáki G
记忆模型通常强调需要对感觉驱动所施加的新的神经活动模式进行编码。另一方面，先前的学习和先天结构可能会限制神经可塑性。在这里，我们测试如何纳入合成海马信号的约束预先存在的电路动态。我们光遗传学刺激了一小群CA 1神经元，因为小鼠穿越了一段选定的线性轨道，模仿了位置场的出现。刺激诱导的持续性位置场重映射在刺激和非刺激神经元。位置场的出现可以从新位置场位置的零星放电和光遗传学扰动之前与对等神经元的时间关系来预测。回路的改变反映在连接的锥体细胞和抑制性中间神经元之间的棘波传递的改变，这种改变在经历后的睡眠中持续存在。我们假设光遗传学扰动揭露了阈下位置场。可塑性在复发/侧抑制可能会通过现有的状态快速协会驱动学习。McKenzie，Huszar等人表明，CA 1锥体神经元的光遗传学去极化诱导位置场出现在具有弱的预先存在的驱动的位置。刺激还改变锥体细胞和中间神经元之间的突触耦合强度。反馈/侧抑制的重组可能是海马神经计算长期变化的机制之一。
Memory models often emphasize the need to encode novel patterns of neural activity imposed by sensory drive. On the other hand, prior learning and innate architecture likely restrict neural plasticity. Here, we test how incorporation of synthetic hippocampal signals is constrained by pre-existing circuit dynamics. We optogenetically stimulated small groups of CA1 neurons as mice traversed a chosen segment of a linear track, mimicking the emergence of place fields. Stimulation induced persistent place field remapping in stimulated and non-stimulated neurons. Emergence of place fields could be predicted from sporadic firing in the new place field location and the temporal relationship to peer neurons prior to the optogenetic perturbation. Circuit modification was reflected by altered spike transmission between connected pyramidal cells and inhibitory interneurons, which persisted during post-experience sleep. We hypothesize that optogenetic perturbation unmasked sub-threshold place fields. Plasticity in recurrent/lateral inhibition may drive learning through rapid association of existing states. McKenzie, Huszar et al. show that optogenetic depolarization of CA1 pyramidal neurons induces place fields to emerge in locations with weak pre-existing drive. Stimulation also alters synaptic coupling strength between pyramidal cells and interneurons. Reorganization of feedback/lateral inhibition may be one mechanism for long-lasting changes in hippocampal neural computation.
登录
查看更多内容
影响因子：
7.8
作者：
Battaglia, FP;Sutherland, GR;Harris, KD
通讯作者：
Harris, KD
影响因子：
25
作者：
Fujisawa, Shigeyoshi;Amarasingham, Asohan;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
影响因子：
56.9
作者：
Galarreta, M;Hestrin, S
通讯作者：
Hestrin, S
DOI：
10.1073/pnas.1421056111
发表时间：
2014-12-30
影响因子：
11.1
作者：
Alme, Charlotte B.;Miao, Chenglin;Moser, May-Britt
通讯作者：
Moser, May-Britt
影响因子：
16.2
作者：
English DF;McKenzie S;Evans T;Kim K;Yoon E;Buzsáki G
通讯作者：
Buzsáki G