Pyramidal Cell-Interneuron Circuit Architecture and Dynamics in Hippocampal Networks.
Pyramidal Cell-Interneuron Circuit Architecture and Dynamics in Hippocampal Networks.
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DOI：
10.1016/j.neuron.2017.09.033
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发表时间：
2017-10-11
期刊：
影响因子：
16.2
通讯作者：
Buzsáki G
中科院分区：
文献类型：
--
作者：
English DF;McKenzie S;Evans T;Kim K;Yoon E;Buzsáki G
由于在活体内研究突触连接的困难，抑制神经元的兴奋控制知之甚少。我们通过分析棘波计时来推断这种连接，并通过对行为小鼠突触前棘波的细胞旁和光遗传控制来验证这一推断。我们观察到邻近的CA1神经元有更强的联系，浅层锥体细胞向深层中间神经元投射更多。连接的概率和强度是不平衡的，只有少数高度连接的枢纽。不同的突触前连接导致了中间神经元之间的同步。汇聚的突触前输入的同步性促进了突触后的驱动。突触前放电频率由突触后神经元通过短期抑制和促进而读出，单个锥体细胞和中间神经元显示不同的棘波传递过滤器。此外，突触后细胞先前的棘波时序强烈地调制了棘波的传递。这些结果将解剖结构与生理功能联系起来。
Excitatory control of inhibitory neurons is poorly understood due to the difficulty of studying synaptic connectivity in vivo. We inferred such connectivity through analysis of spike timing and validated this inference using juxtacellular and optogenetic control of presynaptic spikes in behaving mice. We observed that neighboring CA1 neurons had stronger connections, and that superficial pyramidal cells projected more to deep interneurons. Connection probability and strength were skewed, with a minority of highly connected hubs. Divergent presynaptic connections led to synchrony between interneurons. Synchrony of convergent presynaptic inputs boosted postsynaptic drive. Presynaptic firing frequency was read out by postsynaptic neurons through short-term depression and facilitation, with individual pyramidal cells and interneurons displaying a diversity of spike transmission filters. Additionally, spike transmission was strongly modulated by prior spike timing of the postsynaptic cell. These results bridge anatomical structure with physiological function.
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