Determinants of bone mineral density in obese premenopausal women.
Determinants of bone mineral density in obese premenopausal women.
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DOI：
10.1016/j.bone.2010.12.011
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发表时间：
2011-04-01
期刊：
影响因子：
4.1
通讯作者：
Miller, Karen K.
中科院分区：
文献类型：
--
作者：
Bredella, Miriam A.;Torriani, Martin;Ghomi, Reza Hosseini;Thomas, Bijoy J.;Brick, Danielle J.;Gerweck, Anu V.;Harrington, Lindsey M.;Breggia, Anne;Rosen, Clifford J.;Miller, Karen K.
尽管肥胖是心血管疾病和糖尿病的危险因素，但人们认为肥胖可以预防骨质疏松症。然而，最近的研究表明，特定的脂肪隔室对骨矿物质密度（BMD）的不同影响，内脏脂肪组织（VAT）对BMD具有潜在的不利影响。内脏性肥胖还与GH/IGF-1轴的失调有关，GH/IGF-1轴是骨稳态的重要调节器。本研究的目的是评估腹部脂肪库和肌肉、维生素D和激素决定因素（包括胰岛素样生长因子-1（IGF-1）、睾酮和雌二醇）对腰椎骨小梁BMD的不同影响。我们研究了68名健康的绝经前肥胖妇女（平均BMI：36.7 ± 4.2 kg/m2）。定量计算机断层扫描（QCT）用于评估身体成分和腰椎骨小梁BMD。BMD和VAT之间呈负相关，与年龄和BMI无关（p= 0.003）。IGF-1与BMD呈正相关，与VAT呈负相关，在逐步多元回归模型中，IGF-1是BMD和1型前胶原氨基末端前肽（P1 NP）的最强预测因子。大腿肌肉横截面积（CSA）和大腿肌肉密度也与BMD相关（p<0.05），但25-羟基维生素D [25（OH）D]、睾酮、游离睾酮和雌二醇水平与BMD无关。25（OH）D与BMI、腹部脂肪总量和皮下脂肪量呈负相关（p< 0.05）。这些研究结果支持这一假设，增值税发挥不利的影响，而肌肉质量发挥积极作用的骨密度在绝经前肥胖妇女。此外，我们的研究结果表明，IGF-1可能是增值税对骨健康的有害影响，通过对骨形成的影响介导。
Despite being a risk factor for cardiovascular disease and diabetes mellitus, obesity has been thought to protect against osteoporosis. However, recent studies have demonstrated a differential impact of specific fat compartments on bone mineral density (BMD) with visceral adipose tissue (VAT) having potential detrimental effects on BMD. Visceral obesity is also associated with dysregulation of the GH/IGF-1 axis, an important regulator of bone homeostasis. The purpose of our study was to evaluate the differential effects of abdominal fat depots and muscle, vitamin D, and hormonal determinants, including insulin-like growth factor-1 (IGF-1), testosterone, and estradiol, on trabecular BMD of the lumbar spine. We studied 68 healthy obese premenopausal women (mean BMI: 36.7 ± 4.2 kg/m2). Quantitative computed tomography (QCT) was used to assess body composition and lumbar trabecular BMD. There was an inverse association between BMD and VAT, independent of age and BMI (p= 0.003). IGF-1 correlated positively with BMD and negatively with VAT and, in stepwise multivariate regression modeling, was the strongest predictor of BMD and procollagen type 1 amino-terminal propeptide (P1NP). Thigh muscle cross sectional area (CSA), and thigh muscle density were also associated with BMD (p<0.05), but 25-hydroxyvitamin D [25(OH)D], testosterone, free testosterone and estradiol levels were not. 25(OH)D was associated inversely with BMI, total and subcutaneous abdominal adipose tissue (p< 0.05). These findings support the hypothesis that VAT exerts detrimental effects, whereas muscle mass exerts positive effects on BMD in premenopausal obese women. Moreover, our findings suggest that IGF-1 may be a mediator of the deleterious effects of VAT on bone health through effects on bone formation.
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影响因子：
11.1
作者：
Kristinsson, JÖ;Valdimarsson, Ö;Steingrimsdottir, L
通讯作者：
Steingrimsdottir, L
影响因子：
5.8
作者：
Miller, KK;Rosner, W;Klibanski, A
通讯作者：
Klibanski, A
DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
影响因子：
5
作者：
Konradsen, Steinar;Ag, Harald;Jorde, Rolf
通讯作者：
Jorde, Rolf
影响因子：
4.9
作者：
Papakitsou, EF;Margioris, AN;Stergiopoulos, K
通讯作者：
Stergiopoulos, K