Widespread, long-term admixture between grey wolves and domestic dogs across Eurasia and its implications for the conservation status of hybrids.
Widespread, long-term admixture between grey wolves and domestic dogs across Eurasia and its implications for the conservation status of hybrids.
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DOI：
10.1111/eva.12595
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发表时间：
2018-06
影响因子：
4.1
通讯作者：
Wayne RK
中科院分区：
文献类型：
--
作者：
Pilot M;Greco C;vonHoldt BM;Randi E;Jędrzejewski W;Sidorovich VE;Konopiński MK;Ostrander EA;Wayne RK
驯化物种与其野生祖先之间的杂交是一个重要的保护问题，特别是当它导致驯化基因变体渗入野生物种时。然而，混合动力的法律地位仍然不受监管，部分原因是对混合过程及其后果的了解有限。灰狼和家犬之间杂交的发生在狼地理范围的不同地区都有详细记录，但人们对杂交事件的频率、其原因以及对狼种群的遗传影响知之甚少。我们分析了欧亚大陆和北美狼的犬科动物基因组中的 61K 个 SNP，并将该数据与来自狗的类似数据进行比较，以识别混合物的特征。单倍型块分析包括 38 个常染色体和 X 染色体，表明大多数欧亚狼种群中存在狼狗混合血统的个体，但北美狼种群中存在较少的混合。我们发现了狗等位基因向狼种群中雄性偏向渗入的证据，而且还发现了母狗和公狼交配产生的第一代杂交种。我们在所研究的 62% 欧亚狼的基因组中发现了小块狗血统，而黑变个体没有近期混合血统的迹象，但在与黑变病相关的基因座上有一个源自狗的等位基因。因此，这些结果表明杂交已经在欧亚大陆的不同地区在多个时间尺度上发生，而不仅仅是最近的现象。尽管如此，狼种群仍然保持着与狗的遗传分化，这表明低频率的杂交并不会削弱狼基因库的独特性。然而，杂交频率的增加可能对狼群有害，强调需要进行基因监测来评估最近杂交产生的个体的频率和分布。
Hybridisation between a domesticated species and its wild ancestor is an important conservation problem, especially if it results in the introgression of domestic gene variants into wild species. Nevertheless, the legal status of hybrids remains unregulated, partially because of the limited understanding of the hybridisation process and its consequences. The occurrence of hybridisation between grey wolves and domestic dogs is well documented from different parts of the wolf geographic range, but little is known about the frequency of hybridisation events, their causes and the genetic impact on wolf populations. We analysed 61K SNPs spanning the canid genome in wolves from across Eurasia and North America and compared that data to similar data from dogs to identify signatures of admixture. The haplotype block analysis, which included 38 autosomes and the X chromosome, indicated the presence of individuals of mixed wolf–dog ancestry in most Eurasian wolf populations, but less admixture was present in North American populations. We found evidence for male‐biased introgression of dog alleles into wolf populations, but also identified a first‐generation hybrid resulting from mating between a female dog and a male wolf. We found small blocks of dog ancestry in the genomes of 62% Eurasian wolves studied and melanistic individuals with no signs of recent admixed ancestry, but with a dog‐derived allele at a locus linked to melanism. Consequently, these results suggest that hybridisation has been occurring in different parts of Eurasia on multiple timescales and is not solely a recent phenomenon. Nevertheless, wolf populations have maintained genetic differentiation from dogs, suggesting that hybridisation at a low frequency does not diminish distinctiveness of the wolf gene pool. However, increased hybridisation frequency may be detrimental for wolf populations, stressing the need for genetic monitoring to assess the frequency and distribution of individuals resulting from recent admixture.
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影响因子：
9.8
作者：
Boyko AR;Quignon P;Li L;Schoenebeck JJ;Degenhardt JD;Lohmueller KE;Zhao K;Brisbin A;Parker HG;vonHoldt BM;Cargill M;Auton A;Reynolds A;Elkahloun AG;Castelhano M;Mosher DS;Sutter NB;Johnson GS;Novembre J;Hubisz MJ;Siepel A;Wayne RK;Bustamante CD;Ostrander EA
通讯作者：
Ostrander EA
DOI：
10.1126/science.1165448
发表时间：
2009-03-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anderson TM;vonHoldt BM;Candille SI;Musiani M;Greco C;Stahler DR;Smith DW;Padhukasahasram B;Randi E;Leonard JA;Bustamante CD;Ostrander EA;Tang H;Wayne RK;Barsh GS
通讯作者：
Barsh GS
DOI：
10.1146/annurev-animal-022114-110937
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 5
影响因子：
--
作者：
Freedman, Adam H.;Wayne, Robert K.
通讯作者：
Wayne, Robert K.
影响因子：
3.1
作者：
Harrison, Richard G.;Larson, Erica L.
通讯作者：
Larson, Erica L.
影响因子：
1.6
作者：
Andersone, Z;Lucchini, V;Ozolins, J
通讯作者：
Ozolins, J