Surveillance for seasonal influenza virus prevalence in hospitalized children with lower respiratory tract infection in Guangzhou, China during the post-pandemic era.
Surveillance for seasonal influenza virus prevalence in hospitalized children with lower respiratory tract infection in Guangzhou, China during the post-pandemic era.
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大流行时代，中国广州的医院下呼吸道感染儿童的季节性流感病毒患病率的监测。
DOI：
10.1371/journal.pone.0120983
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chen DH
中科院分区：
文献类型：
--
作者：
Guan WD;Gong XY;Mok CK;Chen TT;Wu SG;Pan SH;Cowling BJ;Yang ZF;Chen DH
自2009年猪源性人类H1N1大流行以来，甲型H1N1流感pdm09、甲型H3N2型流感和乙型流感病毒在人类人群中共同传播。虽然这些亚型的感染通常会导致轻微的疾病，但部分儿童会发生下呼吸道感染(LRTI)并需要住院。我们研究的目的是评估这三种亚型在广州地区住院儿童下呼吸道感染中的患病率，并比较流行后时期广州地区儿童下呼吸道感染的临床表现。对2010年1月至2012年12月收治的儿童下呼吸道感染患儿的咽拭子标本进行甲型/乙型流感病毒检测，并对阳性病例的临床特征进行分析。在3637名住院儿童中，216名(5.9%)确诊为甲型或乙型流感阳性。2010-2012年广州地区流感病毒感染高峰在每年3月左右，各亚型均有不同程度的流行。总体而言，甲型H3N1流感感染的检测频率高于甲型H1N1流感pdm09和乙型流感。感染甲型流感病毒(H1N1/H3N2)的儿童的平均年龄比感染B型流感的儿童年轻(34.4月/32.5月比45月；p<；0.005)。儿童甲型流感/乙型流感与肺炎支原体混合感染44例(20.3%)。中国，这项研究有助于了解广州市下呼吸道感染住院儿童流行后季节性流感病毒的流行情况。肺炎支原体与流感病毒混合感染率高可能是住院儿童病情严重的原因之一。
Influenza A(H1N1)pdm09, A(H3N2) and B viruses have co-circulated in the human population since the swine-origin human H1N1 pandemic in 2009. While infections of these subtypes generally cause mild illnesses, lower respiratory tract infection (LRTI) occurs in a portion of children and required hospitalization. The aim of our study was to estimate the prevalence of these three subtypes and compare the clinical manifestations in hospitalized children with LRTI in Guangzhou, China during the post-pandemic period. Children hospitalized with LRTI from January 2010 to December 2012 were tested for influenza A/B virus infection from their throat swab specimens using real-time PCR and the clinical features of the positive cases were analyzed. Of 3637 hospitalized children, 216 (5.9%) were identified as influenza A or B positive. Infection of influenza virus peaked around March in Guangzhou each year from 2010 to 2012, and there were distinct epidemics of each subtype. Influenza A(H3N2) infection was more frequently detected than A(H1N1)pdm09 and B, overall. The mean age of children with influenza A virus (H1N1/H3N2) infection was younger than those with influenza B (34.4 months/32.5 months versus 45 months old; p<0.005). Co-infections of influenza A/ B with mycoplasma pneumoniae were found in 44/216 (20.3%) children. This study contributes the understanding to the prevalence of seasonal influenza viruses in hospitalized children with LRTI in Guangzhou, China during the post pandemic period. High rate of mycoplasma pneumoniae co-infection with influenza viruses might contribute to severe disease in the hospitalized children.
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影响因子：
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