Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone.
Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone.
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通过聚醚醚酮上纳米氮化硅的生物活性涂层促进体外成骨细胞反应并改善体内骨整合
DOI：
10.1016/j.jot.2019.10.011
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发表时间：
2020-09
影响因子：
6.6
通讯作者：
Shang X
中科院分区：
文献类型：
--
作者：
Dai Y;Guo H;Chu L;He Z;Wang M;Zhang S;Shang X
在保持聚醚醚酮（PEEK）机械强度的同时提高其生物活性。
悬浮涂层和熔融结合。
氮化硅（Si₃N₄，SN）涂层导致更高的表面粗糙度、亲水性和蛋白质吸附；SN涂层可将Si离子缓慢释放到模拟体液（SBF）中，由于SN的轻微溶解，导致微环境呈弱碱性；SN涂层使MC3T3 - E1细胞在体外的黏附、增殖、分化和基因表达得到改善；具有生物活性SN涂层的PEEK（CSNPK）的SN涂层在体内明显促进骨再生和骨整合。
具有SN涂层的CSNPK作为骨植入物可能是骨科植入物的一个有前途的候选者。
本文制备的氮化硅涂层聚醚醚酮（CSNPK）在体外可诱导MC3T3 - E1细胞黏附、增殖和分化；在体内骨缺损处也可诱导骨再生，这表明它具有良好的细胞相容性和生物相容性。如果原材料是医用级的，并且本文的制备工艺以及生产工艺进一步改进，它将具有很大的转化潜力。
To enhance the bioactivity of polyetheretherketone (PEEK) while maintain its mechanical strengths. Suspension coating and melt bonding. Silicon nitride (Si3N4, SN) coating lead to higher surface roughness, hydrophilicity and protein absorption; SN coating could slowly release Si ion into simulated body fluid (SBF), which caused weak alkaline of micro-environment owing to the slight dissolution of SN; SN coating resulted in the improvements of adhesion, proliferation, differentiation and gene expressions of MC3T3-E1 cells in vitro; SN coating of PEEK with bioactive SN coating (CSNPK) obviously promoted bone regeneration and osseointegration in vivo. CSNPK with SN coating as bone implant might be a promising candidate for orthopedic implants. The silicon nitride-coated polyetheretherketone (CSNPK) prepared in this article could induce MC3T3-E1 cells adhesion, proliferation and differentiation in vitro; it could also induce bone regeneration in bone defect in vivo, which indicate its good cytocompatibility and biocompatibility. If the raw materials are medical grade, and preparation process as well as production process of this article are further improved, it will have great translational potential.
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