A Mediterranean-style low-glycemic-load diet increases plasma carotenoids and decreases LDL oxidation in women with metabolic syndrome.
A Mediterranean-style low-glycemic-load diet increases plasma carotenoids and decreases LDL oxidation in women with metabolic syndrome.
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DOI：
10.1016/j.jnutbio.2011.02.016
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发表时间：
2012-06
影响因子：
5.6
通讯作者：
Fernandez, Maria Luz
中科院分区：
文献类型：
--
作者：
Barona, Jacqueline;Jones, Jennifer J.;Kopec, Rachel E.;Comperatore, Michael;Andersen, Catherine;Schwartz, Steven J.;Lerman, Robert H.;Fernandez, Maria Luz
35名患有代谢综合征和高血浆低密度脂蛋白（LDL）胆固醇（≥100 mg/dl）的女性参与了一项饮食干预，包括12周的地中海式低血糖负荷饮食。参与者被随机分配到只食用饮食（n=15）或饮食加含有大豆蛋白和植物甾醇的医疗食品（n=20）。测定血浆类胡萝卜素、脂蛋白亚组分和氧化低密度脂蛋白（OxLDL）浓度。在12周后，与治疗无关，女性的血浆叶黄素（P<.0001）和β-胡萝卜素（P<.0001）显著增加，而血浆番茄红素减少（P<.05）。低密度脂蛋白胆固醇从138±35降至114±33 mg/dl（P<0.0001）。此外，还观察到致动脉粥样硬化亚组分的减少：大极低密度脂蛋白（P<0.05），小LDL（P<0.00001）和中等高密度脂蛋白（P<0.05）。两组的氧化低密度脂蛋白均显著降低12%（P<0.01）。OxLDL的变化与血浆叶黄素呈负相关（r=-0.478，P<0.0001）。数据表明，妇女通过增加水果和蔬菜的摄入量来遵守饮食方案。减少经常与富含番茄红素的番茄酱料（如意大利面和比萨饼）共同食用的高血糖食物的消费可能是12周后血浆中类胡萝卜素降低的原因。这些结果还表明，血浆叶黄素浓度可以通过降低OxLDL的浓度来防止氧化应激。
Thirty-five women with metabolic syndrome and high plasma low-density lipoprotein (LDL) cholesterol (≥100 mg/dl) participated in a dietary intervention consisting of a Mediterranean-style low-glycemic-load diet for 12 weeks. Participants were randomly allocated to consume diet only (n=15) or diet plus a medical food containing soy protein and plant sterols (n=20). Plasma concentrations of carotenoids, lipoprotein subfractions and oxidized LDL (OxLDL) were measured. Independent of treatment, women had a significant increase in plasma lutein (P<.0001) and β-carotene (P<.0001), while plasma lycopene was reduced (P<.05) after 12 weeks. Low-density lipoprotein cholesterol was reduced from 138±35 to 114±33 mg/dl (P<.0001). In addition, decreases were observed in the atherogenic subfractions: large very low-density lipoprotein (P<.05), small LDL (P<.00001) and medium high-density lipoprotein (P<.05). Oxidized LDL was significantly reduced by 12% in both groups (P<.01). Changes in OxLDL were inversely correlated with plasma lutein (r=−.478, P<.0001). The data indicate that women complied with the dietary regimen by increasing fruits and vegetable intake. Decreased consumption of high-glycemic foods frequently co-consumed with lycopene-rich tomato sauce such as pasta and pizza may be responsible for the lowering of this carotenoid in plasma after 12 weeks. These results also suggest that plasma lutein concentrations may protect against oxidative stress by reducing the concentrations of OxLDL.
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影响因子：
4.5
作者：
Djuric, Zora;Ren, Jianwei;Sen, Ananda
通讯作者：
Sen, Ananda
影响因子：
5.8
作者：
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通讯作者：
Riccioni, Graziano
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4.7
作者：
Al-Delaimy, WK;Ferrari, P;Riboli, E
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Riboli, E
影响因子：
6.1
作者：
Kopec RE;Riedl KM;Harrison EH;Curley RW Jr;Hruszkewycz DP;Clinton SK;Schwartz SJ
通讯作者：
Schwartz SJ
影响因子：
3.9
作者：
Levy, Y;Zaltsberg, H;Aviram, M
通讯作者：
Aviram, M