Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review.
Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review.
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DOI：
10.1186/s12931-018-0754-7
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发表时间：
2018-03-27
影响因子：
5.8
通讯作者：
Zinellu A
中科院分区：
文献类型：
--
作者：
Fois AG;Paliogiannis P;Sotgia S;Mangoni AA;Zinellu E;Pirina P;Carru C;Zinellu A
特发性肺纤维化(IPF)是一种病因不明的致死性肺部疾病，以慢性进行性纤维化性间质性肺炎为特征，进行性损害肺功能。氧化应激是IPF的主要致病途径之一。这项系统性综述的目的是描述不同生物标本中确定的氧化应激标志物的类型，以及抗氧化剂治疗对特发性肺纤维化患者的影响。我们对电子数据库(Pubmed、Web of Science、Scope us和Google Scholar)从成立到2017年10月收录的出版物进行了系统检索。两名调查人员独立审查了所有确定的文章，以确定是否符合条件。在最初确定的文章(n = 554)中有很大一部分因重复、摘要、无关或不符合选择标准而被排除后，我们确定了30项研究。在每项研究中，我们都严格评估了氧化应激生物标志物的类型、部位(全身性和局部性，例如呼吸、痰、呼出气冷凝液、上皮衬套液、支气管肺泡灌洗和肺组织标本)，以及用于测量已识别的氧化应激生物标记物的方法。并对特发性肺纤维化抗氧化治疗的研究现状进行了综述。在特发性肺纤维化患者中，已经描述了许多氧化应激标志物，它们具有个体优势和局限性。然而，抗氧化剂治疗的试验一直无法证明一致的好处，除非最近的药物基因组学数据表明，在IPF患者的特定基因型亚组中有不同的结果。
Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF. The aim of this systematic review was to describe the type of markers of oxidative stress identified in different biological specimens and the effects of antioxidant therapies in patients with IPF. We conducted a systematic search of publications listed in electronic databases (Pubmed, Web of Science, Scopus and Google Scholar) from inception to October 2017. Two investigators independently reviewed all identified articles to determine eligibility. After a substantial proportion of the initially identified articles (n = 554) was excluded because they were duplicates, abstracts, irrelevant, or did not meet the selection criteria, we identified 30 studies. In each study, we critically appraised the type, site (systemic vs. local, e.g. breath, sputum, expired breath condensate, epithelial lining fluid, bronchoalveolar lavage, and lung tissue specimens), and method used for measuring the identified oxidative stress biomarkers. Furthermore, the current knowledge on antioxidant therapies in IPF was summarized. A number of markers of oxidative stress, with individual advantages and limitations, have been described in patients with IPF. Nevertheless, trials of antioxidant treatments have been unable to demonstrate consistent benefits, barring recent pharmacogenomics data suggesting different results in specific genotype subgroups of patients with IPF.
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影响因子：
24.3
作者：
Beeh, KM;Beier, J;Buhl, R
通讯作者：
Buhl, R
影响因子：
5
作者：
Bargagli, Elena;Penza, Francesco;Rottoli, Paola
通讯作者：
Rottoli, Paola
影响因子：
3.2
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Daniil, Zoe D.;Papageorgiou, Evangelia;Gourgoulianis, Konstantinos I.
通讯作者：
Gourgoulianis, Konstantinos I.
影响因子：
4.3
作者：
Jackson, R.;Ramos, C.;Gomez-Marin, O.
通讯作者：
Gomez-Marin, O.
影响因子：
9.6
作者：
Kanoh, S;Kobayashi, H;Motoyoshi, K
通讯作者：
Motoyoshi, K