Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk.
Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk.
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DOI：
10.1016/j.leukres.2008.06.031
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发表时间：
2009-02
影响因子：
2.7
通讯作者：
Kang, Daehee
中科院分区：
文献类型：
--
作者：
Lee, Kyoun -Mu;Ward, Mary H.;Han, Sohee;Ahn, Hyo Seop;Kang, Hyoung Jin;Choi, Hyung Soo;Shin, Hee Young;Koo, Hong-Hoe;Seo, Jong-Jin;Choi, Ji-Eun;Ahn, Yoon-Ok;Kang, Daehee
我们进行了一项病例对照研究，以评估父亲吸烟与儿童白血病之间的关联，并评估CYP1A1基因多态性对其的潜在修饰作用。从韩国首尔的三家教学医院招募了经组织学确诊的儿童白血病病例（n = 164）和非癌症对照（n = 164）。对CYP1A1基因的五个单核苷酸多态性（–17961T>C、–9893G>A、I462V、1188C>T（*2A）和11599C>G）进行了基因分型，并通过期望最大化方法估算了单倍型。我们还对12项已报道父亲吸烟与儿童白血病风险之间关联的研究进行了荟萃分析。在家中父亲吸烟与所有白血病（比值比 = 1.8，95%置信区间 = 1.1 - 2.8）以及急性淋巴细胞白血病（ALL）（2.0，1.2 - 3.4）相关。出生后吸烟的包年数（趋势P值分别为0.06和0.02）以及孩子一生中家中吸烟者的数量（趋势P值分别为0.05和0.03）都观察到风险呈上升趋势。在那些不具有CGACC单倍型的人群中，父亲在家中吸烟（2.8，1.5 - 5.3）以及家中至少有一名吸烟者（2.3，1.2 - 4.4）会使ALL风险显著增加，并且交互作用检验显著（交互作用P值分别为0.03和0.02）。荟萃分析表明，总体上父亲吸烟（1.13，1.04 - 1.24）以及在孩子受孕前吸烟（1.12，1.04 - 1.21）与儿童白血病风险显著相关。我们的研究结果表明，父亲吸烟是儿童白血病的一个风险因素，并且其影响可能会被CYP1A1基因型所修饰。
We conducted a case–control study to evaluate the association between paternal smoking and childhood leukemia and to evaluate potential modification by polymorphisms in CYP1A1. Histologically confirmed childhood leukemia cases (n = 164) and non-cancer controls (n = 164) were recruited from three teaching hospitals in Seoul, Korea. Five single nucleotide polymorphisms in CYP1A1 (–17961T>C, –9893G>A, I462V, 1188C>T (*2A), and 11599C>G) were genotyped and haplotypes were estimated by the expectation-maximization method. We also conducted a meta-analysis of 12 studies that have reported the association between paternal smoking and childhood leukemia risk. Paternal smoking at home was associated with all leukemias (OR = 1.8, 95% CI = 1.1–2.8) and acute lymphoblastic leukemia (ALL) (2.0, 1.2–3.4). An increasing trend in risk was observed for pack-years smoked after birth (Ptrend = 0.06 and 0.02, respectively) and the number of smokers in the home during the child's life (Ptrend = 0.05 and 0.03, respectively). Among those without the CGACC haplotype, ALL risk was significantly increased by the father's smoking at home (2.8, 1.5–5.3) and the presence of at least one smoker in the home (2.3, 1.2–4.4), and the test for interaction was significant (Pinteraction = 0.03 and 0.02, respectively). The meta-analysis showed that overall paternal smoking (1.13, 1.04–1.24) and smoking before the pregnancy of the child (1.12, 1.04–1.21) were significantly associated with childhood leukemia risk. Our results suggest that paternal smoking is a risk factor for childhood leukemia and the effect may be modified by CYP1A1 genotype.
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DOI：
10.1016/s1383-5718(03)00051-2
发表时间：
2003-05-09
影响因子：
1.9
作者：
Horak, S;Polanska, J;Widlak, P
通讯作者：
Widlak, P
影响因子：
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作者：
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作者：
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Theriault, Gilles
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作者：
Clavel, J;Bellec, S;Loriot, MA
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Loriot, MA