Soy food intake and circulating levels of inflammatory markers in Chinese women.
Soy food intake and circulating levels of inflammatory markers in Chinese women.
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DOI：
10.1016/j.jand.2012.04.001
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发表时间：
2012-07
影响因子：
4.8
通讯作者：
Yang, Gong
中科院分区：
文献类型：
--
作者：
Wu, Sheng Hui;Shu, Xiao Ou;Chow, Wong-Ho;Xiang, Yong-Bing;Zhang, Xianglan;Li, Hong-Lan;Cai, Qiuyin;Ji, Bu-Tian;Cai, Hui;Rothman, Nathaniel;Gao, Yu-Tang;Zheng, Wei;Yang, Gong
大豆及其一些成分，如异黄酮类，已经在动物研究中被证明影响炎症过程。在人类中，大豆食物摄入量和炎症标志物之间的联系还没有得到充分的评估。我们的目的是评估在1005名中国中年女性中，较高的大豆食物摄入量是否与炎症标记物呈负相关。在这项横断面研究中，大豆食品的饮食摄入量通过有效的食物频率问卷和24小时回想购买生物检疫剂的时间来评估。在调整了年龄、生活方式和饮食因素以及感染或炎症相关疾病的病史后，采用一般线性模型估计了选定的炎症标志物的几何平均值，包括白介素6(IL-6)、白介素1(IL-1)β、肿瘤坏死因子-α(TWF-α)、可溶性IL-6受体、可溶性gp130、可溶性肿瘤坏死因子受体1和2以及C反应蛋白。我们发现，多变量调整后的几何平均值IL-6和肿瘤坏死因子α浓度与大豆食物摄入量呈负相关，IL-6的最高和最低五分位数之间的差异分别为25.5%(趋势P=0.008)和14%(P趋势=0.04)。当以过去24小时内食用大豆的频率评估时，肿瘤坏死因子α(P=0.003.0 1)、可溶性肿瘤坏死因子受体1(P=0.0 1)、可溶性肿瘤坏死因子受体2(P=0.0 2)、IL-1β(P=0.0 5)和IL-6(P=0.0 4)呈类似的负相关关系。没有发现与其他被研究的标记有显著的关联。本研究提示，大豆食品的摄入与中国女性循环中IL-6、肿瘤坏死因子α和可溶性肿瘤坏死因子受体1、2水平降低有关。
Soy and some of its constituents, such as isoflavones, have been shown to affect the inflammatory process in animal studies. The association between soy food intake and inflammatory markers has not been evaluated adequately in humans. Our aim was to evaluate whether higher intake of soy foods was inversely associated with inflammatory markers in 1,005 middle-aged Chinese women. In this cross-sectional study, dietary intake of soy foods was assessed by a validated food frequency questionnaire and by a 24-hour recall when biospecimens were procured. A general linear model was used to estimate the geometric means of selected inflammatory markers, including interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNFα), soluble IL-6 receptor, soluble GP130, soluble TNF receptors 1 and 2, and C-reactive protein, across categories of soy food intake after adjusting for age, lifestyle and dietary factors, and history of infectious or inflammation-related diseases. We found that multivariable-adjusted geometric mean concentrations of IL-6 and TNFα were inversely associated with quintiles of soy food intake, with a difference between the highest and lowest quintiles of 25.5% for IL-6 (P for trend = 0.008) and 14% for TNFα (P for trend = 0.04). Similar inverse associations were found for TNFα (P for trend = 0.003), soluble TNF receptor 1 (P for trend=0.01), soluble TNF receptor 2 (P for trend=0.02), IL-1β (P for trend=0.05), and IL-6 (P for trend=0.04) when soy food consumption was assessed by the frequency of consumption in the preceding 24 hours. No significant associations were found for other markers studied. This study suggests that soy food consumption is related to lower circulating levels of IL-6, TNFα, and soluble TNF receptors 1 and 2 in Chinese women.
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影响因子：
6.3
作者：
Giovannini S;Onder G;Liperoti R;Russo A;Carter C;Capoluongo E;Pahor M;Bernabei R;Landi F
通讯作者：
Landi F
影响因子：
4.6
作者：
Hämäläinen M;Nieminen R;Vuorela P;Heinonen M;Moilanen E
通讯作者：
Moilanen E
影响因子：
--
作者：
Liu, Simin;Tinker, Lesley;Manson, JoAnn E.
通讯作者：
Manson, JoAnn E.
血清中肿瘤标记，趋化因子和与转移相关的分子的可靠性。
影响因子：
2.8
作者：
Linkov F;Gu Y;Arslan AA;Liu M;Shore RE;Velikokhatnaya L;Koenig KL;Toniolo P;Marrangoni A;Yurkovetsky Z;Zeleniuch-Jacquotte A;Lokshin AE
通讯作者：
Lokshin AE
DOI：
10.1158/1055-9965.epi-11-0221
发表时间：
2011-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Chaturvedi AK;Kemp TJ;Pfeiffer RM;Biancotto A;Williams M;Munuo S;Purdue MP;Hsing AW;Pinto L;McCoy JP;Hildesheim A
通讯作者：
Hildesheim A