Bovine Immune Factors Underlying Tick Resistance: Integration and Future Directions.
Bovine Immune Factors Underlying Tick Resistance: Integration and Future Directions.
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DOI：
10.3389/fcimb.2017.00522
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发表时间：
2017
影响因子：
5.7
通讯作者：
Maritz-Olivier C
中科院分区：
文献类型：
--
作者：
Robbertse L;Richards SA;Maritz-Olivier C
牛品种内部和品种之间的蜱虫抗性机制已经研究了几十年。以前的几篇关于牛免疫参数对蜱虫抗性的论文讨论了DNA、RNA、蛋白质、细胞和组织水平的发现。然而，牛宿主种类、蜱虫种类和实验布局之间的差异并没有得到充分的考虑。本综述旨在(a)全面总结调查不同蜱虫抗性牛品种之间免疫标记差异的研究，以及(b)整合关键发现，并就驱动抗性的可能免疫调节途径提出假设。实验问题可能会使结论产生偏差，这一点得到了强调。未来，改进的实验策略将使更有针对性的研究能够识别和整合免疫标记和/或途径。到目前为止，最具结论性的是组胺、粒细胞及其相关途径在蜱虫抗性机制中的作用。有趣的是，与不同的品种相比，不同的免疫标记物可能参与单一宿主品种的机制。此外，每个蜱虫生命阶段的差异是明显的，这限制了数据集可以比较的水平。未来的研究需要进一步阐明整个蜱虫生命周期的免疫分子动力学，并在分子和细胞水平上深入研究有前途的标记和途径，以获得关于蜱虫抗性驱动因素的科学合理的假设。
The mechanisms underlying tick resistance within and between cattle breeds have been studied for decades. Several previous papers on bovine immune parameters contributing to tick resistance discussed findings across DNA, RNA, protein, cellular, and tissue levels. However, the differences between bovine host species, tick species and the experimental layouts were not always taken into account. This review aims to (a) give a comprehensive summary of studies investigating immune marker differences between cattle breeds with varying degrees of tick resistance, and (b) to integrate key findings and suggest hypotheses on likely immune-regulated pathways driving resistance. Experimental issues, which may have skewed conclusions, are highlighted. In future, improved experimental strategies will enable more focused studies to identify and integrate immune markers and/or pathways. Most conclusive thus far is the involvement of histamine, granulocytes and their associated pathways in the tick-resistance mechanism. Interestingly, different immune markers might be involved in the mechanisms within a single host breed in contrast to between breeds. Also, differences are evident at each tick life stage, limiting the level to which datasets can be compared. Future studies to further elucidate immune molecule dynamics across the entire tick life cycle and in-depth investigation of promising markers and pathways on both molecular and cellular level are in dire need to obtain a scientifically sound hypothesis on the drivers of tick resistance.
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影响因子：
2.1
作者：
Carvalho, Wanessa Araujo;Bechara, Gervasio Henrique;Ferreira de Miranda Santos, Isabel K.
通讯作者：
Ferreira de Miranda Santos, Isabel K.
影响因子：
2.4
作者：
GILL, HS
通讯作者：
GILL, HS
牛宿主之间皮肤的免疫和生化反应在遗传上易感性和对牛tick tick tick ripicephalus microplus的抗药性不同。
影响因子：
3.2
作者：
Franzin AM;Maruyama SR;Garcia GR;Oliveira RP;Ribeiro JM;Bishop R;Maia AA;Moré DD;Ferreira BR;Santos IK
通讯作者：
Santos IK
影响因子：
2.6
作者：
Carvalho, Wanessa Araujo;Domingues, Robert;Machado, Marco Antonio
通讯作者：
Machado, Marco Antonio
DOI：
10.1111/j.1749-6632.2000.tb05338.x
发表时间：
2000-01-01
期刊：
TROPICAL VETERINARY DISEASES
影响因子：
--
作者：
Bechara, GH;Morelli, J;Szabó, MPJ
通讯作者：
Szabó, MPJ