Auditory cortical activity elicited by infrared laser irradiation from the outer ear in Mongolian gerbils.
Auditory cortical activity elicited by infrared laser irradiation from the outer ear in Mongolian gerbils.
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听觉皮质活性是由蒙古语沙鼠外耳的红外激光照射引起的。
DOI：
10.1371/journal.pone.0240227
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Kobayasi KI
中科院分区：
文献类型：
--
作者：
Tamai Y;Ito Y;Furuyama T;Horinouchi K;Murashima N;Michimoto I;Hishida R;Shibuki K;Hiryu S;Kobayasi KI
红外神经刺激已被研究其取代人工耳蜗电刺激的潜力。然而，没有研究揭示这种技术是如何可靠地唤起听觉皮层活动的。本研究利用线粒体黄蛋白荧光信号活动依赖性变化的脑成像研究外耳激光刺激耳蜗对听觉皮层的影响。一根光纤被插入沙鼠的耳道，用红外激光刺激耳蜗的外侧。发现激光刺激可以激活已识别的初级听觉皮层。此外，激光诱发反应的时间分布与听觉反应相当。我们的研究结果表明，来自外耳的红外激光照射有能力唤起并可能操纵听觉皮层的神经活动，并可能在未来取代目前的人工耳蜗。
Infrared neural stimulation has been studied for its potential to replace an electrical stimulation of a cochlear implant. No studies, however, revealed how the technic reliably evoke auditory cortical activities. This research investigated the effects of cochlear laser stimulation from the outer ear on auditory cortex using brain imaging of activity-dependent changes in mitochondrial flavoprotein fluorescence signal. An optic fiber was inserted into the gerbil’s ear canal to stimulate the lateral side of the cochlea with an infrared laser. Laser stimulation was found to activate the identified primary auditory cortex. In addition, the temporal profile of the laser-evoked responses was comparable to that of the auditory responses. Our results indicate that infrared laser irradiation from the outer ear has the capacity to evoke, and possibly manipulate, the neural activities of the auditory cortex and may substitute for the present cochlear implants in future.
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影响因子：
64.8
作者：
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影响因子：
2.8
作者：
Capsius, B;Leppelsack, HJ
通讯作者：
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