Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.
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DOI：
10.1038/s41370-023-00603-4
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发表时间：
2023-09
影响因子：
4.5
通讯作者：
Deziel NC
中科院分区：
文献类型：
--
作者：
Rosen Vollmar AK;Lin EZ;Nason SL;Santiago K;Johnson CH;Ma X;Godri Pollitt KJ;Deziel NC
近年来，小儿甲状腺疾病呈上升趋势。接触化学污染物等环境风险因素可能发挥一定作用，但在很大程度上尚未得到探索。存档的新生儿干血斑 (DBS) 提供了一种研究环境暴露和影响的创新方法。在这项试点研究中，我们应用了一种新方法对 1985 年至 2018 年在加利福尼亚州出生的婴儿的 18 个存档 DBS 进行定量全氟烷基物质和多氟烷基物质 (PFAS)，并从新生儿筛查测试中获取了甲状腺激素测量值。利用这些新数据，我们评估了 (1) 八种 PFAS 浓度随时间的变化，以及 (2) PFAS 浓度、甲状腺激素浓度和新生儿特征之间的关系，为未来的研究提供信息。使用超高效液相色谱-质谱法测量 DBS 中的 PFAS 浓度。摘要统计数据、非参数 Wilcoxon 秩和和 Kruskal-Wallis 检验用于评估 PFAS 浓度的时间变化以及 PFAS 浓度、甲状腺激素浓度和新生儿特征之间的关系。评估期间，多种 PFAS（PFOA、PFOS 和 PFOSA）的浓度和检测频率有所下降。我们观察到，出生后数小时内采集标本的时间与甲状腺激素有关，但与 PFAS 浓度无关，并且甲状腺激素与某些 PFAS 浓度（PFOA 和 PFOS）有关。这项初步研究考察了 33 年来收集的新生儿干血斑 (DBS) 中八种全氟烷基物质和多氟烷基物质 (PFAS) 的浓度、甲状腺激素水平和新生儿特征之间的关系。据我们所知，我们尝试测量的 22 种 PFAS 中，有 6 种以前未在新生儿 DBS 中进行量化，这是第一项使用 DBS 检查 PFAS 和甲状腺激素浓度的研究。这项研究证明了在基于人群的研究中使用新生儿 DBS 来量化 PFAS 暴露的可行性，强调了在使用新生儿 DBS 进行未来研究时使用甲状腺激素数据的方法学考虑，并指出了 PFAS 浓度与甲状腺激素之间的潜在关系，以供未来研究的后续研究。
Pediatric thyroid diseases have been increasing in recent years. Environmental risk factors such as exposures to chemical contaminants may play a role but are largely unexplored. Archived neonatal dried blood spots (DBS) offer an innovative approach to investigate environmental exposures and effects. In this pilot study, we applied a new method for quantifying per- and polyfluoroalkyl substances (PFAS) to 18 archived DBS from babies born in California from 1985–2018 and acquired thyroid hormone measurements from newborn screening tests. Leveraging these novel data, we evaluated (1) changes in the concentrations of eight PFAS over time and (2) the relationship between PFAS concentrations, thyroid hormone concentrations, and neonatal characteristics to inform future research. PFAS concentrations in DBS were measured using ultra-high-performance liquid chromatography-mass spectrometry. Summary statistics and non-parametric Wilcoxon rank-sum and Kruskal–Wallis tests were used to evaluate temporal changes in PFAS concentrations and relationships between PFAS concentrations, thyroid hormone concentrations, and neonatal characteristics. The concentration and detection frequencies of several PFAS (PFOA, PFOS, and PFOSA) declined over the assessment period. We observed that the timing of specimen collection in hours after birth was related to thyroid hormone but not PFAS concentrations, and that thyroid hormones were related to some PFAS concentrations (PFOA and PFOS). This pilot study examines the relationship between concentrations of eight per- and polyfluoroalkyl substances (PFAS), thyroid hormone levels, and neonatal characteristics in newborn dried blood spots (DBS) collected over a period of 33 years. To our knowledge, 6 of the 22 PFAS we attempted to measure have not been quantified previously in neonatal DBS, and this is the first study to examine both PFAS and thyroid hormone concentrations using DBS. This research demonstrates the feasibility of using newborn DBS for quantifying PFAS exposures in population-based studies, highlights methodological considerations in the use of thyroid hormone data for future studies using newborn DBS, and indicates potential relationships between PFAS concentrations and thyroid hormones for follow-up in future research.
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影响因子：
8.3
作者：
Barr DB;Kannan K;Cui Y;Merrill L;Petrick LM;Meeker JD;Fennell TR;Faustman EM
通讯作者：
Faustman EM
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
2.8
作者：
Kharrazi M;Pearl M;Yang J;DeLorenze GN;Bean CJ;Callaghan WM;Grant A;Lackritz E;Romero R;Satten GA;Simhan H;Torres AR;Westover JB;Yolken R;Williamson DM
通讯作者：
Williamson DM
Fernald 社区队列中纵向血清全氟烷基物质 (PFAS) 水平与甲状腺激素、肾功能和体重指数测量之间的关联。
DOI：
10.1016/j.envpol.2018.07.042
发表时间：
2018-11
期刊：
Environmental pollution (Barking, Essex : 1987)
影响因子：
--
作者：
Blake BE;Pinney SM;Hines EP;Fenton SE;Ferguson KK
通讯作者：
Ferguson KK
DOI：
10.1186/1476-069x-13-106
发表时间：
2014-12-10
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
de Cock M;de Boer MR;Lamoree M;Legler J;van de Bor M
通讯作者：
van de Bor M