Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: a randomized controlled trial.
Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: a randomized controlled trial.
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DOI：
10.2337/dc12-0540
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发表时间：
2013-01
期刊：
影响因子：
16.2
通讯作者：
Berneis K
中科院分区：
文献类型：
--
作者：
Aeberli I;Hochuli M;Gerber PA;Sze L;Murer SB;Tappy L;Spinas GA;Berneis K
高热量、高果糖饮食对人类受试者胰岛素敏感性和脂质的不良影响已被反复证明。然而，接近日常消费量的果糖的影响尚未得到充分研究。本研究评估了与葡萄糖相比，适量果糖和蔗糖对葡萄糖和脂质代谢的影响。在这项双盲、随机、交叉试验中，对9名健康、体重正常的男性志愿者（年龄21-25岁）进行了研究。所有受试者饮用四种不同的加糖饮料（600 mL/天），各持续3周：40 g/天的中果糖（MF），以及80 g/天的高果糖（HF）、高葡萄糖（HG）和高蔗糖（HS）。使用具有[6，6]-2H2葡萄糖标记的正常血糖-高胰岛素血症钳夹来测量内源性葡萄糖产生。在空腹样本中测量血脂、血糖和胰岛素。在钳夹过程中，HF（59.4 ± 11.0%）对肝脏葡萄糖生成的抑制显著低于HG（70.3 ± 10.5%，P < 0.05），而空腹血糖、胰岛素和C肽在两种干预措施之间没有差异。与高糖组相比，MF、HF和HS后LDL胆固醇和总胆固醇显著升高（P < 0.05），游离脂肪酸显著升高（P < 0.05）。受试者在干预期间的能量摄入与基线摄入没有显著差异。这项研究清楚地表明，与等量的葡萄糖相比，适量的果糖和蔗糖显著改变肝脏胰岛素敏感性和脂质代谢。
Adverse effects of hypercaloric, high-fructose diets on insulin sensitivity and lipids in human subjects have been shown repeatedly. The implications of fructose in amounts close to usual daily consumption, however, have not been well studied. This study assessed the effect of moderate amounts of fructose and sucrose compared with glucose on glucose and lipid metabolism. Nine healthy, normal-weight male volunteers (aged 21–25 years) were studied in this double-blind, randomized, cross-over trial. All subjects consumed four different sweetened beverages (600 mL/day) for 3 weeks each: medium fructose (MF) at 40 g/day, and high fructose (HF), high glucose (HG), and high sucrose (HS) each at 80 g/day. Euglycemic-hyperinsulinemic clamps with [6,6]-2H2 glucose labeling were used to measure endogenous glucose production. Lipid profile, glucose, and insulin were measured in fasting samples. Hepatic suppression of glucose production during the clamp was significantly lower after HF (59.4 ± 11.0%) than HG (70.3 ± 10.5%, P < 0.05), whereas fasting glucose, insulin, and C-peptide did not differ between the interventions. Compared with HG, LDL cholesterol and total cholesterol were significantly higher after MF, HF, and HS, and free fatty acids were significantly increased after MF, but not after the two other interventions (P < 0.05). Subjects’ energy intake during the interventions did not differ significantly from baseline intake. This study clearly shows that moderate amounts of fructose and sucrose significantly alter hepatic insulin sensitivity and lipid metabolism compared with similar amounts of glucose.
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影响因子：
9.8
作者：
Schneiter, P;Gillet, M;Tappy, L
通讯作者：
Tappy, L
DOI：
10.1152/ajpendo.1999.276.1.e188
发表时间：
1999-01-01
影响因子：
5.1
作者：
Berneis, K;Ninnis, R;Keller, U
通讯作者：
Keller, U
影响因子：
3.6
作者：
Sock, Emilienne Tudor Ngo;Le, Kim-Anne;Tappy, Luc
通讯作者：
Tappy, Luc
影响因子：
120.7
作者：
Welsh, Jean A.;Sharma, Andrea;Abramson, Jerome L.;Vaccarino, Viola;Gillespie, Cathleen;Vos, Miriam B.
通讯作者：
Vos, Miriam B.
影响因子：
5.8
作者：
Stanhope, Kimber L.;Bremer, Andrew A.;Havel, Peter J.
通讯作者：
Havel, Peter J.