Effect of Sow Intestinal Flora on the Formation of Endometritis.
Effect of Sow Intestinal Flora on the Formation of Endometritis.
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母猪肠道菌群对子宫内膜炎形成的影响
DOI：
10.3389/fvets.2021.663956
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发表时间：
2021
影响因子：
3.2
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Zhang L;Wang L;Dai Y;Tao T;Wang J;Wu Y;Zeng X;Zhang J
子宫内膜炎是导致母猪繁殖性能下降的主要原因，而母猪子宫内膜炎病因中最重要的因素之一是产道微生物群的异常。因此，人们开始关注母猪产道微生物群结构和组成。有趣的是，我们在临床实践中发现，便秘母猪发生肠炎的风险增加，这可能意味着肠道植物群与肠炎的发生有关。因此，了解产道微生物群和宿主肠道微生物群之间的关系变得尤为重要。本研究通过对4头健康母猪和4头母猪的产道分泌物和新鲜粪便中细菌16S核糖体（rDNA）基因V3 + V4区进行测序，分析了产道分泌物和新鲜粪便中的微生物群。结果表明，肠炎母猪产道植物群的组成和丰富度与健康母猪产道有显著差异。厚壁菌门（74.36%）和变形菌门是健康母猪产道微生物群中的优势菌门。然而，属于厚壁菌门的大多数有益细菌（例如，乳杆菌和肠球菌）在仔猪中下降。Porphyromonas，Clostridium sensu stricto 1，Streptococcus，Fusobacterium，Actinobacillus和Bacteroides在母猪产道微生物群中的丰度显著增加。土氏志贺菌属和拟杆菌属是母猪产道和肠道植物群的常见菌属。患肠炎母猪肠道中的土氏志贺菌和类杆菌的丰度显著高于健康母猪肠道菌群。根据对母猪肠炎和健康母猪肠道菌群的分析，我们推测某些肠道细菌（如土氏志贺菌和拟杆菌）可能与母猪肠炎的发病有关。以上结果为研究母猪产道炎的发病机制提供了理论依据，有助于人们了解母猪产道及肠道菌群与产道及肠道菌群的关系。
Endometritis is the main cause of decreased reproductive performance of sows, while one of the most important factors in the etiology of sow endometritis is an aberration of birth canal microbiota. Therefore, people began to pay attention to the microbiota structure and composition of the birth canal of sows with endometritis. Interestingly, we found that the risk of endometritis was increased in the sows with constipation in clinical practice, which may imply that the intestinal flora is related to the occurrence of endometritis. Therefore, understanding the relationship between birth canal microbiota and intestinal microbiota of the host has become exceptionally crucial. In this study, the microbiota of birth canal secretions and fresh feces of four healthy and four endometritis sows were analyzed via sequencing the V3 + V4 region of bacterial 16S ribosomal (rDNA) gene. The results showed a significant difference between endometritis and healthy sows birth canal flora in composition and abundance. Firmicutes (74.36%) and Proteobacteria were the most dominant phyla in birth canal microbiota of healthy sows. However, the majority of beneficial bacteria that belonging to Firmicutes phylum (e.g., Lactobacillus and Enterococcus) declined in endometritis sow. The abundance of Porphyromonas, Clostridium sensu stricto 1, Streptococcus, Fusobacterium, Actinobacillus, and Bacteroides increased significantly in the birth canal microbiota of endometritis sows. Escherichia–Shigella and Bacteroides were the common genera in the birth canal and intestinal flora of endometritis sows. The abundance of Escherichia–Shigella and Bacteroides in the intestines of sows suffering from endometritis were significantly increased than the intestinal microbiota of the healthy sows. We speculated that some intestinal bacteria (such as Escherichia–Shigella and Bacteroides) might be bound up with the onset of sow endometritis based on intestinal microbiota analysis in sows with endometritis and healthy sows. The above results can supply a theoretical basis to research the pathogenesis of endometritis and help others understand the relationship with the microbiota of sow's birth canal and gut.
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影响因子：
2.2
作者：
Koh HW;Kim MS;Lee JS;Kim H;Park SJ
通讯作者：
Park SJ
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影响因子：
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作者：
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影响因子：
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作者：
Wang Y;Zhang H;Zhu L;Xu Y;Liu N;Sun X;Hu L;Huang H;Wei K;Zhu R
通讯作者：
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影响因子：
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作者：
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通讯作者：
Ooshima, Takashi
影响因子：
4.4
作者：
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通讯作者：
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