Rapid activation of esophageal mechanoreceptors alters the pharyngeal phase of swallow: Evidence for inspiratory activity during swallow.
Rapid activation of esophageal mechanoreceptors alters the pharyngeal phase of swallow: Evidence for inspiratory activity during swallow.
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DOI：
10.1371/journal.pone.0248994
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Pitts T
中科院分区：
文献类型：
--
作者：
Frazure ML;Brown AD;Greene CL;Iceman KE;Pitts T
吞咽是一个复杂的行为，包括三个协调的阶段：口腔、咽和食道。食管膨胀（EDist）已被证明引起咽吞咽，但EDist诱导咽吞咽的生理特征尚未明确描述。我们研究了在自主呼吸的戊巴比妥钠麻醉猫（n = 5）中，在有或没有口服水刺激的情况下，快速EDist对口咽吞咽的影响。采用肌电图（emg）评估8块肌肉的吞咽情况：mylohyoid （MyHy）、geniohyoid （GeHy）、甲状舌骨（ThHy）、甲状咽肌（ThPh）、甲状舌肌（ThAr）、环咽肌（食管上括约肌：UES）、胸骨旁肌（PS）和肋隔膜（Dia）。吞咽被定义为上呼吸道活动重叠的UES的静止，并在三种刺激条件下进行分析：1)仅口咽输水，2)仅食管快速膨胀（EDist）， 3)联合刺激。结果显示，不同刺激条件对大鼠下颌舌骨肌、膝舌骨肌、甲状腱肌、膈肌和UES肌的吞咽肌电图振幅有显著影响。总的来说，我们发现，与单独的颈部食管快速扩张相比，快速扩张联合输水的刺激条件与喉内收肌和膈肌吞咽相关肌电活动（schluckatmung）增加以及吞咽后UES恢复相关。我们假设食管上段扩张的这些作用激活了脑干吞咽网络，并通过启动和/或调节咽吞咽反应来保护气道。
Swallow is a complex behavior that consists of three coordinated phases: oral, pharyngeal, and esophageal. Esophageal distension (EDist) has been shown to elicit pharyngeal swallow, but the physiologic characteristics of EDist-induced pharyngeal swallow have not been specifically described. We examined the effect of rapid EDist on oropharyngeal swallow, with and without an oral water stimulus, in spontaneously breathing, sodium pentobarbital anesthetized cats (n = 5). Electromyograms (EMGs) of activity of 8 muscles were used to evaluate swallow: mylohyoid (MyHy), geniohyoid (GeHy), thyrohyoid (ThHy), thyropharyngeus (ThPh), thyroarytenoid (ThAr), cricopharyngeus (upper esophageal sphincter: UES), parasternal (PS), and costal diaphragm (Dia). Swallow was defined as quiescence of the UES with overlapping upper airway activity, and it was analyzed across three stimulus conditions: 1) oropharyngeal water infusion only, 2) rapid esophageal distension (EDist) only, and 3) combined stimuli. Results show a significant effect of stimulus condition on swallow EMG amplitude of the mylohyoid, geniohyoid, thyroarytenoid, diaphragm, and UES muscles. Collectively, we found that, compared to rapid cervical esophageal distension alone, the stimulus condition of rapid distension combined with water infusion is correlated with increased laryngeal adductor and diaphragm swallow-related EMG activity (schluckatmung), and post-swallow UES recruitment. We hypothesize that these effects of upper esophageal distension activate the brainstem swallow network, and function to protect the airway through initiation and/or modulation of a pharyngeal swallow response.
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影响因子：
2.5
作者：
German, Rebecca Z.;Crompton, A. W.;Thexton, Allan J.
通讯作者：
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影响因子：
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CHERNIACK, NS
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