Biomarkers of periodontal tissue remodeling during orthodontic tooth movement in mice and men: overview and clinical relevance.
Biomarkers of periodontal tissue remodeling during orthodontic tooth movement in mice and men: overview and clinical relevance.
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DOI：
10.1155/2013/105873
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发表时间：
2013
影响因子：
--
通讯作者：
Perillo L
中科院分区：
文献类型：
--
作者：
d'Apuzzo F;Cappabianca S;Ciavarella D;Monsurrò A;Silvestrini-Biavati A;Perillo L
牙周组织内的细胞响应正畸矫治器的机械刺激而表达生物活性物质。提出了几种可能的生物标志物，代表特定现象期间的生物修饰，例如炎症过程、骨吸收和形成、牙周膜变化以及血管和神经反应。通过搜索 PubMed、Cochrane 数据库和科学教科书来引用可能发表的试验。此外，还进行了手工检索并与该领域的专家联系，以确定可能相关的已发表和未发表的研究。选择标准如下：动物模型仅涉及接受正畸治疗的小鼠和大鼠；龈沟液（GCF）的采集作为一种对人体无创的操作；没有其他同时治疗可能影响实验性正畸运动。数据表明，了解正畸和矫形治疗期间牙周组织中发生的重塑过程可能是一种临床有用的程序，可以导致正确选择机械应力，以改善和缩短治疗时间，避免不良后果。强调了临床医生通过小鼠和男性两种研究模型来评估某些物质作为正畸运动期间牙周影响的有效生物标志物的比率的相关性。
Biologically active substances are expressed by cells within the periodontium in response to mechanical stimuli from orthodontic appliances. Several possible biomarkers representing biological modifications during specific phenomena as simile-inflammatory process, bone resorption and formation, periodontal ligament changes, and vascular and neural responses are proposed. Citations to potentially published trials were conducted by searching PubMed, Cochrane databases, and scientific textbooks. Additionally, hand searching and contact with experts in the area were undertaken to identify potentially relevant published and unpublished studies. Selection criteria were as follows: animal models involving only mice and rats undergoing orthodontic treatment; collection of gingival crevicular fluid (GCF) as a noninvasively procedure for humans; no other simultaneous treatment that could affect experimental orthodontic movement. The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences. The relevance for clinicians of evaluating the rate of some substances as valid biomarkers of periodontal effects during orthodontic movement, by means of two models of study, mice and men, is underlined.
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影响因子：
3.1
作者：
Batra, P;Kharbanda, Op;Parkash, H
通讯作者：
Parkash, H
DOI：
10.1016/s0889-5406(96)70152-x
发表时间：
1996-03-01
影响因子：
3
作者：
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通讯作者：
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Zainal Ariffin Z
影响因子：
7.6
作者：
Kaku, M;Kohno, S;Tanne, K
通讯作者：
Tanne, K
影响因子：
1.2
作者：
Kaku, Masato;Motokawa, Masahide;Tanne, Kazuo
通讯作者：
Tanne, Kazuo