Vaccination against Feline Panleukopenia: implications from a field study in kittens.
Vaccination against Feline Panleukopenia: implications from a field study in kittens.
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针对猫的疫苗接种：小猫的一项现场研究的影响。
DOI：
10.1186/1746-6148-8-62
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发表时间：
2012-05-21
影响因子：
2.6
通讯作者：
Duchow K
中科院分区：
文献类型：
--
作者：
Jakel V;Cussler K;Hanschmann KM;Truyen U;König M;Kamphuis E;Duchow K
猫泛白细胞减少症（FPL）是猫的一种严重疾病，可以通过接种疫苗预防。小猫在出生后的头几个月里经常反复接种疫苗。此时，母源性抗体（MDA）可以干扰疫苗接种并抑制主动免疫的发展。Paul-Ehrlich研究所收到的关于接种种猫FPL暴发的频繁报告质疑了田间条件下初次接种的有效性。因此，我们启动了一项田间研究，以研究在FPL初次接种期间小猫免疫力的发展。来自16窝的64只小猫在8、12和16周龄时使用三种商业多价疫苗接种FPL。在每次接种前和20周龄时采集血样。在两个独立的诊断实验室通过血凝抑制试验和血清中和试验检测血清中的猫泛白细胞减少症病毒（FPV）抗体。在不同实验室和不同方法获得的结果之间有很好的相关性。尽管进行了三联疫苗接种，但36.7%的小猫未发生血清转化。即使是非常低滴度的MDA也明显抑制主动免疫的发展。大多数小猫在8周龄和12周龄时显示出显著的MDA滴度;在一些动物中，在20周龄时仍检测到MDA。有趣的是，测试的疫苗在克服低水平母体免疫力的能力方面存在显着差异。在给定的情况下，建议在小猫初次接种前定量测定女王或小猫血清中的FPV抗体。初次疫苗接种的开始应推迟，直到MDA滴度下降。经血清学鉴定为无保护的小猫应重新接种。
Feline Panleukopenia (FPL) is a serious disease of cats that can be prevented by vaccination. Kittens are routinely vaccinated repeatedly during their first months of life. By this time maternally derived antibodies (MDA) can interfere with vaccination and inhibit the development of active immunity. The efficacy of primary vaccination under field conditions was questioned by frequent reports to the Paul-Ehrlich-Institut on outbreaks of FPL in vaccinated breeding catteries. We therefore initiated a field study to investigate the development of immunity in kittens during primary vaccination against FPL. 64 kittens from 16 litters were vaccinated against FPL at the age of 8, 12 and 16 weeks using three commercial polyvalent vaccines. Blood samples were taken before each vaccination and at the age of 20 weeks. Sera were tested for antibodies against Feline Panleukopenia Virus (FPV) by hemagglutination inhibition test and serum neutralisation assay in two independent diagnostic laboratories. There was a good correlation between the results obtained in different laboratories and with different methods. Despite triple vaccination 36.7% of the kittens did not seroconvert. Even very low titres of MDA apparently inhibited the development of active immunity. The majority of kittens displayed significant titres of MDA at 8 and 12 weeks of age; in some animals MDA were still detected at 20 weeks of age. Interestingly, the vaccines tested differed significantly in their ability to overcome low levels of maternal immunity. In the given situation it is recommended to quantify antibodies against FPV in the serum of the queen or kittens before primary vaccination of kittens. The beginning of primary vaccination should be delayed until MDA titres have declined. Unprotected kittens that have been identified serologically should be revaccinated.
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DOI：
10.2460/javma.2002.220.38
发表时间：
2002-01-01
期刊：
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
影响因子：
--
作者：
Lappin, MR;Andrews, J;Jensen, WA
通讯作者：
Jensen, WA
影响因子：
2.2
作者：
LUFF, PR;WOOD, GW;THORNTON, DH
通讯作者：
THORNTON, DH
影响因子：
2.2
作者：
FASTIER, LB
通讯作者：
FASTIER, LB
影响因子：
0.8
作者：
Poulet, H.
通讯作者：
Poulet, H.
影响因子：
1.7
作者：
Dawson, S;Willoughby, K;Chalmers, W S
通讯作者：
Chalmers, W S