An open access resource for functional brain connectivity from fully awake marmosets.
An open access resource for functional brain connectivity from fully awake marmosets.
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一个开放获取的资源，用于完全清醒的绒猴的功能性大脑连接。
DOI：
10.1016/j.neuroimage.2022.119030
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发表时间：
2022-05-15
期刊：
影响因子：
5.7
通讯作者：
Silva, Afonso C.
中科院分区：
文献类型：
--
作者：
Schaeffer, David J.;Klassen, L. Martyn;Hori, Yuki;Tian, Xiaoguang;Szczupak, Diego;Yen, Cecil Chern-Chyi;Clery, Justine C.;Gilbert, Kyle M.;Gati, Joseph S.;Menon, Ravi S.;Liu, CiRong;Everling, Stefan;Silva, Afonso C.
关键词：
常见的绒猴(Callithrix Jacchus)作为一种主要的神经科学模型正在迅速获得吸引力。然而，在理解绒猴大脑的功能和结构组织方面仍需要相当大的进展，以与长期存在的临床前模式物种，如小鼠、大鼠和东半球灵长类动物的组织相媲美。为了加速这一进展，我们提供了Marmoset功能连接资源(marmosetbrainConnectome.org)，其中包括在一个普通立体定向空间中以500μm各向同性分辨率获取的超过70小时的静息状态功能磁共振(RS-fMRI)数据，这些数据来自31只完全清醒的绒猴。每个皮质和皮质下灰质体素的三维功能连接性(FC)图在线存储。用户可以即时查看、操作和下载任何全脑功能连接(FC)拓扑(在主题或组级别)以及原始数据集和预处理代码。重要的是，研究人员可以利用这一资源直接测试关于FC的假说--不需要额外的分析--根据需要产生任何灰质体素的全脑相关性。我们展示了资源对于术前计划的效用，并与作为概念验证的基于示踪剂的结构连通性进行了比较。作为对现有绒猴大脑结构连接资源的补充，Marmoset功能连接资源为用户提供了探索绒猴大脑中任何体素的连接的独特优势，不限于注射部位，也不受区域地图集的限制。随着整个原始数据库(RS-fMRI和结构图像)和预处理代码的公开下载和使用，我们预计这些资源将对测试关于绒猴大脑功能组织的新假设具有广泛的价值。
The common marmoset (Callithrix jacchus) is quickly gaining traction as a premier neuroscientific model. However, considerable progress is still needed in understanding the functional and structural organization of the marmoset brain to rival that documented in long-standing preclinical model species, like mice, rats, and Old World primates. To accelerate such progress, we present the Marmoset Functional Connectivity Resource (marmosetbrainconnectome.org), consisting of over 70 hours of resting-state fMRI (RS-fMRI) data acquired at 500 μm isotropic resolution from 31 fully awake marmosets in a common stereotactic space. Three-dimensional functional connectivity (FC) maps for every cortical and subcortical gray matter voxel are stored online. Users can instantaneously view, manipulate, and download any whole-brain functional connectivity (FC) topology (at the subject- or group-level) along with the raw datasets and preprocessing code. Importantly, researchers can use this resource to test hypotheses about FC directly – with no additional analyses required – yielding whole-brain correlations for any gray matter voxel on demand. We demonstrate the resource’s utility for presurgical planning and comparison with tracer-based structural connectivity as proof of concept. Complementing existing structural connectivity resources for the marmoset brain, the Marmoset Functional Connectivity Resource affords users the distinct advantage of exploring the connectivity of any voxel in the marmoset brain, not limited to injection sites nor constrained by regional atlases. With the entire raw database (RS-fMRI and structural images) and preprocessing code openly available for download and use, we expect this resource to be broadly valuable to test novel hypotheses about the functional organization of the marmoset brain.
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影响因子：
5.7
作者：
Hung CC;Yen CC;Ciuchta JL;Papoti D;Bock NA;Leopold DA;Silva AC
通讯作者：
Silva AC
影响因子：
5.7
作者：
Liu, Junjie V.;Hirano, Yoshiyuki;Nascimento, George C.;Stefanovic, Bojana;Leopold, David A.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
影响因子：
16.2
作者：
Miller CT;Freiwald WA;Leopold DA;Mitchell JF;Silva AC;Wang X
通讯作者：
Wang X
影响因子：
5.7
作者：
Hikishima, K.;Quallo, M. M.;Okano, H.
通讯作者：
Okano, H.
影响因子：
5.3
作者：
Hung, Chia-Chun;Yen, Cecil C.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.