Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during Helicobacter pylori Infection.
Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during Helicobacter pylori Infection.
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DOI：
10.5009/gnl220464
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发表时间：
2024-01-15
期刊：
影响因子：
3.4
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Khangai A;Akada J;Saruuljavkhlan B;Gantuya B;Azzaya D;Oyuntsetseg K;Davaadorj D;Uchida T;Matsumoto T;Yamaoka Y
乳胶凝集浊度（LA）检测血清抗体已在日本和韩国获批用于幽门螺杆菌感染的大规模筛查。在这项研究中，我们评估了LA检测诊断H。蒙古人群的幽门螺杆菌感染和预测胃粘膜变化。共鉴定出484株H. pylori阳性（n=356）和H.幽门螺杆菌阴性组（n=128），通过组织学和H.幽门培养。LA检测的最佳临界值、灵敏度和特异性值分别为18.35 U/mL、74.2%和65.6%。萎缩性胃炎组的LA值显著高于其他组（健康组、慢性胃炎组、肠上皮化生组和胃癌组，p<0.0001）。萎缩性胃炎组与其他四组的临界值为32.0 U/mL，其曲线下面积为0.673，这是我们数据中E平板、胃蛋白酶原（PG）I、PG II和PG I/II比值试验中最高的。在多元Logistic回归中，LA检测和PG I检测确定的萎缩性胃炎的比值比分别为2.5和1.9，显著高于其他检测。LA测定可以确定萎缩性胃炎的风险，而萎缩性胃炎又是胃癌的一个相当大的风险因素。我们建议将该检测方法与PG I/II比值结合使用，以避免遗漏LA值较低（小于32.0 U/mL）的胃癌患者。
A latex agglutination turbidity (LA) assay to test for serum antibodies has been approved in Japan and Korea for mass screening of Helicobacter pylori infection. In this study, we evaluated the LA assay for diagnosing H. pylori infection and predicting gastric mucosal changes in a Mongolian population. In total, 484 individuals were classified into H. pylori-positive (n=356) and H. pylori-negative (n=128) groups, as determined by histology and H. pylori culture. The best cutoff, sensitivity, and specificity values for the LA assay were 18.35 U/mL, 74.2%, and 65.6%, respectively. The LA values in the atrophic gastritis group were statistically higher than those in the other groups (healthy, chronic gastritis, intestinal metaplasia, and gastric cancer, p<0.0001). The cutoff value to distinguish the atrophic gastritis group from the other four groups was 32.0 U/mL, and its area under the curve was 0.673, which was the highest among the E-plate, pepsinogen (PG) I, PG II, and PG I/II ratio tests in our data. The odds ratios for atrophic gastritis determined by the LA assay and PG I test in multiple logistic regression were 2.5 and 1.9, respectively, which were significantly higher than for the other tests. The LA assay can determine the risk of atrophic gastritis, which in turn is a considerable risk factor for gastric cancer. We propose using this assay in combination with the PG I/II ratio to avoid missing gastric cancer patients who have a low LA value (less than 32.0 U/mL).
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影响因子：
4.2
作者：
Khasag O;Boldbaatar G;Tegshee T;Duger D;Dashdorj A;Uchida T;Matsuhisa T;Yamaoka Y
通讯作者：
Yamaoka Y
DOI：
10.23750/abm.v89i8-s.7910
发表时间：
2018-12-17
期刊：
Acta bio-medica : Atenei Parmensis
影响因子：
--
作者：
Kayali, Stefano;Aloe, Rosalia;De' Angelis, Gian Luigi
通讯作者：
De' Angelis, Gian Luigi
影响因子：
4.3
作者：
Berlth, Felix;Bollschweiler, Elfriede;Moenig, Stefan
通讯作者：
Moenig, Stefan
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
影响因子：
4.3
作者：
Lu, Chien-Yu;Kuo, Chao-Hung;Wu, Deng-Chyang
通讯作者：
Wu, Deng-Chyang