The dorsomedial striatum mediates Pavlovian appetitive conditioning and food consumption.
The dorsomedial striatum mediates Pavlovian appetitive conditioning and food consumption.
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DOI：
10.1037/bne0000216
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发表时间：
2017-12
影响因子：
1.9
通讯作者：
Petrovich GD
中科院分区：
文献类型：
--
作者：
Cole S;Stone AD;Petrovich GD
背内侧纹状体（DMS）是一个重要的感觉运动区域，介导目标导向的工具奖励学习和行为灵活性的获得。然而，DMS 是否也调节巴甫洛夫提示食物学习尚不清楚。目前的研究使用兴奋性毒性损伤来确定 DMS 在巴甫洛夫食欲学习和行为中是否至关重要，并使用判别条件反射和逆转范式。结果表明，DMS 损伤会暂时阻碍提示食物学习，并随后逆转这种学习。患有 DMS 损伤的大鼠在训练早期选择性地减弱对食物信号的反应，但对控制信号的反应没有减弱，这表明在最初的关联形成时 DMS 参与其中。同样，在患有 DMS 损伤的大鼠中，最初的逆转学习能力减弱，这表明当提示意义逆转时，调整行为的灵活性受损。我们还在测试中检查了 DMS 损伤对食物摄入的影响，测试中提供了高度适口的食物和标准的食物。患有 DMS 损伤的大鼠表现出摄入模式的改变，首先是 HFD 减少，随后食物摄入量增加。这些结果表明，DMS 在调节提示食物学习及其随后的逆转以及提供选择时食物摄入的变化方面发挥着作用。总之，这些结果表明，当需要行为灵活性来调整响应或消费以匹配当前值时，DMS 参与奖励联想学习和奖励消费。
The dorsomedial striatum (DMS) is an important sensorimotor region mediating the acquisition of goal-directed instrumental reward learning and behavioral flexibility. However, whether the DMS also regulates Pavlovian cue-food learning is less clear. The current study used excitotoxic lesions to determine whether the DMS is critical in Pavlovian appetitive learning and behavior, using discriminative conditioning and reversal paradigms. The results showed that DMS lesions transiently retarded cue-food learning and subsequent reversal of this learning. Rats with DMS lesions selectively attenuated responding to a food cue but not a control cue, early in training, suggesting the DMS is involved when initial associations are formed. Similarly, initial reversal learning was attenuated in rats with DMS lesions, which suggests impaired flexibility to adjust behavior when the cue meaning is reversed. We also examined the effect of DMS lesions on food intake during tests with access to a highly palatable food along with standard chow diet. Rats with DMS lesions showed an altered pattern of intake, with an initial reduction in HFD followed by an increase in chow consumption. These results demonstrate that the DMS has a role in mediating cue-food learning and its subsequent reversal, as well as changes in food intake when a choice is provided. Together, these results demonstrate the DMS is involved in reward associative learning and reward consumption, when behavioral flexibility is needed to adjust responding or consumption to match the current value.
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影响因子：
2.7
作者：
Ragozzino, Michael E.;Mohler, Eric G.;Prior, Margaret;Palencia, Carlos A.;Roman, Suzanne
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影响因子：
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影响因子：
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通讯作者：
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