Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica.
Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica.
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DOI：
10.1177/1934578x221109426
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发表时间：
2022-07
影响因子：
1.8
通讯作者：
Stevens, Jan F.
中科院分区：
文献类型：
--
作者：
Miranda, Cristobal L.;Kumbi, Yadano;Wu, Wenbin;Lee, Hyi-Seung;Reed, Ralph L.;Stevens, Jan F.
水青冈属植物化学物质因其对人体健康的潜在益处而受到越来越多的关注。水青冈属植物含有黄酮类、生物碱类、皂苷类、萜类、香豆素类和单宁类等多种植物化学成分。在这项研究中，我们研究了水青冈的未水解和酸水解提取物的植物化学成分及其对乳腺癌MCF-7细胞的体外生物活性。结果表明，F. indica含有与报道的该水龙头属物种的植物化学成分一致的植物化学成分，在水解提取物中检测到更大量的糖苷配基。F.发现未经酸水解的印度在剂量低于1000 μg/mL时对抑制MCF-7细胞的生长无效。然而，在酸水解（模拟胃肠道水解）后，F。结果表明，在低浓度（10 μg/mL）时，籼稻提取物对MCF-7细胞的生长有明显的抑制作用，且随着浓度的增加和作用时间的延长，籼稻提取物对MCF-7细胞的杀伤作用逐渐增强。结果表明，F.印度提取物含有糖苷形式的植物化学物质，其糖苷配基在体外作为抗乳腺癌细胞增殖剂具有活性。
Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health. Fagonia species contain various types of phytochemicals such as flavonoids, alkaloids, saponins, terpenoids, coumarins and tannins. In this study, we investigated the phytochemical composition of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica and their bioactivity toward breast cancer MCF-7 cells in vitro. The results revealed that F. indica contains phytochemicals consistent with the reported phytochemical composition of this Fagonia species, with greater amounts of aglycones detected in the hydrolyzed extract. The crude extract of F. indica without acid hydrolysis was found to be ineffective in inhibiting the growth of MCF-7 cells at doses below 1000 μg/mL. However, after acid hydrolysis (to mimic gastro-intestinal hydrolysis), the F. indica extract became growth-inhibitory to MCF-7 cells as low as 10 μg/mL and the cytotoxicity increased with increasing dose and time of treatment. The results suggest that F. indica extracts contain phytochemicals in glycosidic forms whose aglycones are active as anti-proliferative agents toward breast cancer cells in vitro.
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影响因子：
1.7
作者：
Farheen, Rabia;Siddiqui, Bina Shaheen;Majeed, Saba
通讯作者：
Majeed, Saba
DOI：
10.36721/pjps.2021.34.6.sup.2325-2331.1
发表时间：
2021-11-01
影响因子：
0.8
作者：
Khalid, Samrah;Tiwana, Hira;Riaz, Sana
通讯作者：
Riaz, Sana
影响因子：
1.6
作者：
ALWAKEEL, SAM
通讯作者：
ALWAKEEL, SAM
影响因子：
0.6
作者：
Atiq-ur-Rehman;Latif, Abida;Qaisar, Muhammad Naeem
通讯作者：
Qaisar, Muhammad Naeem
影响因子：
2
作者：
Hunke, Megan;Martinez, Wuilian;Chandra, Surabhi
通讯作者：
Chandra, Surabhi