Region E3 of adenovirus: a cassette of genes involved in host immunosurveillance and virus-cell interactions.

Region E3 of adenovirus: a cassette of genes involved in host immunosurveillance and virus-cell interactions.
复制标题

腺病毒的 E3 区:参与宿主免疫监视和病毒与细胞相互作用的基因盒。

DOI:
10.1016/0042-6822(91)90815-s
复制
发表时间:
1991
期刊:
影响因子:
3.7
通讯作者:
Gooding,LR
Gooding,LR
中科院分区:
医学3区
文献类型:
--
作者:
Wold,WS;Gooding,LR

文献摘要

参考文献

被引文献

相似文献

关于病毒的分子生物学,人们已经了解了很多。然而,在分子水平上,关于病毒如何篡夺被感染的细胞以及它们如何与宿主的抗病毒防御相互作用,我们所知甚少。在这篇综述中,我们将讨论几种主要编码在E3转录单元内的新型人腺病毒(Ad)蛋白,它们可能允许腺病毒逃避免疫监视,并可能为感染细胞进行有效的病毒复制做好准备。最近的几篇综述与这一主题相关(PBBbo et al., 1989; Wold and Gooding, 1989; Gooding and Wold, 1990; Horwitz, 1 QQOa)。有47种已知的人类腺病毒血清型(Ad1至Ad47),形成6个不同的组(A至F)。虽然腺病毒通常会感染呼吸道和胃肠道的上皮表面,但血清型和组在组织特异性和毒力方面可能存在显著差异(Horwitz, 1990b)。Ad2和Ad5 (C组)是研究最广泛的,常引起婴幼儿呼吸道感染。感染有时会持续数月甚至数年;淋巴样细胞可能是这些持续性感染的宿主。
A great deal has been learned about the molecular biology of viruses. However, much less is known at the molecular level about how viruses usurp the infected cell and how they interact with the host’s antiviral defenses. In this review, we will discuss several novel human adenovirus (Ad) proteins, coded mainly within the E3 transcription unit, that may allow adenovirus to evade immunosurveillance and that may prepare the infected cell for efficient virus replication. Several recent reviews are related to this topic (PBBbo et al., 1989; Wold and Gooding, 1989; Gooding and Wold, 1990; Horwitz, 1 QQOa).There are 47 known human adenovirus serotypes (Ad1 to Ad47) that form six distinct groups (A to F). Although adenoviruses in general infect epithelial surfaces of the respiratory and GI tracts, the serotypes and groups can differ markedly in tissue specificity and virulence (Horwitz, 1990b). Ad2 and Ad5 (group C), the most extensively studied, commonly cause respiratory infections in infants and young children. Infections occasionally persist for months or even years; lymphoid cells may be the reservoir for these persistent infections.
I 类限制性 T 淋巴细胞的抗原识别。
DOI: 10.1146/annurev.iy.07.040189.003125
发表时间: 1989
影响因子: 29.7
作者:
and A Townsend;H. Bodmer
通讯作者: H. Bodmer
DOI: 10.1073/pnas.75.11.5674
发表时间: 1978-01-01
影响因子: 11.1
作者:
KVIST, S;OSTBERG, L;PETERSON, PA
通讯作者: PETERSON, PA
3 型腺病毒基因组类型的分子流行病学和限制性位点定位
DOI: 10.1128/jcm.27.6.1329-1334.1989
发表时间: 1989
影响因子: 9.4
作者:
T. Adrian;B. Best;J. Hierholzer;R. Wigand
通讯作者: R. Wigand
DOI: 10.1016/0092-8674(89)90866-0
发表时间: 1989
期刊: Cell
影响因子: 64.5
作者:
Patrick Martin;W. Vass;J. Schiller;D. Lowy;T. Velu
通讯作者: T. Velu
两种人类 MHC I 类抗原和腺病毒糖蛋白之间的差异关联。
DOI: 10.4049/jimmunol.137.3.1003
发表时间: 1986
影响因子: 4.4
作者:
L. Severinsson;I. Martens;P. A. Peterson
通讯作者: P. A. Peterson