Short-term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals.
Short-term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals.
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DOI：
10.1038/ijo.2013.84
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发表时间：
2014-02
影响因子：
4.9
通讯作者：
Fairchild, T. J.
中科院分区：
文献类型：
--
作者：
Kanaley, J. A.;Heden, T. D.;Liu, Y.;Whaley-Connell, A. T.;Chockalingam, A.;Dellsperger, K. C.;Fairchild, T. J.
短期运动训练可改善血糖控制，但短期运动训练对餐后饱腹感多肽反应或知觉饱腹感的影响仍不清楚。我们测试了短期有氧运动训练(15天)会改变肥胖者餐后胰腺和肠肽[胰腺多肽(PP)和多肽YY(PYY)]的反应以及感知的食欲和饱腹感的假设。13名健康肥胖男性和女性(年龄：42±2岁；体重指数：30~45 kg/m2)在训练前和训练15d后(70~75%VO2峰值步行1h)进行研究。在研究当天，受试者摄入1500千卡作为6餐(250千卡：蛋白质9克，CHO 40克，脂肪6克)，同时在基线和每20分钟采集血样和测量饱腹感，持续12小时。分析血液中胰多肽(PP)、肽YY(PYY)、血糖和胰岛素水平。全天用视觉模拟标尺评估食欲和饱腹感。PP曲线下增量面积(IAUC)随训练时间的增加而显著增加(训练前为2788±753；训练后12h为3845±830pg/ml.min，p<；0.001)，但对每餐的PP反应无差异。随着训练的进行，对第一餐的初始PP反应增加(ΔPPmin 20-0：Pre 86±25；Post 140±36 pg/ml，p<；0.05)。随着训练的进行，PYY iAUC没有显著变化，但表现出显著的时间主效应，其中最大的反应是对第一顿饭的反应(P<；0.005)。随着训练的进行，饱腹感、血糖或胰岛素水平没有变化。短期运动训练增加了肥胖个体的餐后PP浓度；然而，PYY水平和血糖控制仍然不受影响。PP和PYY在所有餐点都表现出膳食诱导的增加，但PYY在第一餐的反应更大，而在随后的餐点反应减少。
Short-term exercise training improves glycemic control, but the effect of short-term training on postprandial satiety peptide responses or perceived satiety remains unknown. We tested the hypothesis that short-term aerobic exercise training (15 days) would alter postprandial pancreatic and gut peptide [pancreatic polypeptide (PP) and peptide YY (PYY)] responses and perceived appetite and satiety in obese individuals. Thirteen healthy obese men and women (age: 42±2 y; BMI: 30-45 kg/m2) Subjects were studied before and after 15 days of training (walking 1 h at 70-75% VO2peak). On the study day, subjects consumed 1500 kcal as 6 meals (250 kcal: 9 g protein, 40 g CHO, 6 g fat) while blood samples and satiety measurements were taken at baseline and every 20 min for 12 h. Blood was analyzed for pancreatic polypeptide (PP), peptide YY (PYY), glucose, and insulin levels. Appetite and satiety was assessed with a visual analog scale throughout the day. Incremental area under the curve (iAUC) for PP increased significantly with training (pre 2788±753; post 3845±830 pg/ml·min for 12-h, p<0.001), but there was no difference in the PP response to each meal. The initial PP response to the first meal increased (ΔPPmin 20-0: pre 86±25; post 140±36 pg/ml, p<0.05) with training. PYY iAUC showed no significant changes with training but showed a significant main effect of time across meals, with the largest response being to the first meal (P<0.005). There were no changes in satiety, glucose, or insulin levels with training. Short-term exercise training increases postprandial PP concentrations in obese individuals; however, PYY levels and glycemic control remain unaffected. Both PP and PYY show meal-induced increases at all meals but PYY has a greater response at the first meal with reduced responses at subsequent meals.
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影响因子：
7.7
作者：
Maier, Christina;Riedl, Michaela;Luger, Anton
通讯作者：
Luger, Anton
影响因子：
3
作者：
Kahleova, H.;Mari, A.;Pelikanova, T.
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Pelikanova, T.
DOI：
10.1152/ajpregu.90706.2008
发表时间：
2009-01-01
影响因子：
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Broom, David R.;Batterham, Rachel L.;Stensel, David J.
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Stensel, David J.
DOI：
10.1152/ajpregu.90671.2008
发表时间：
2009-02-01
影响因子：
2.8
作者：
Hagobian, Todd A.;Sharoff, Carrie G.;Braun, Barry
通讯作者：
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影响因子：
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作者：
Jones, Terry E.;Basilio, J. L.;Hickner, R. C.
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Hickner, R. C.