Representations of Taste Modality in the Drosophila Brain.
Representations of Taste Modality in the Drosophila Brain.
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DOI：
10.1016/j.neuron.2015.05.026
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发表时间：
2015-06-17
期刊：
影响因子：
16.2
通讯作者：
Scott K
中科院分区：
文献类型：
--
作者：
Harris DT;Kallman BR;Mullaney BC;Scott K
味觉受体和外周味觉细胞已在果蝇和哺乳动物中被发现，这表明感觉细胞可以适应跨物种的味觉模式。高级大脑中枢如何处理味觉模式以指导喂养决策尚未解决。在这里，我们开发了一种大规模钙成像方法与细胞标记相结合，以检查果蝇大脑中如何处理不同的味觉模式。这些研究表明，甜、苦和水感觉细胞激活整个食管下区的不同细胞群，大多数细胞对单一味觉模式做出反应。甜味和苦味的通路从感觉输入到运动输出是分离的，这种分离维持在大脑的高级区域，包括与学习和神经调节有关的区域。我们的工作揭示了食欲和厌恶味道的独立处理，表明果蝇和哺乳动物使用类似的编码策略来确保对显着化合物的先天反应。
Gustatory receptors and peripheral taste cells have been identified in flies and mammals, revealing that sensory cells are tuned to taste modality across species. How taste modalities are processed in higher brain centers to guide feeding decisions is unresolved. Here, we developed a large-scale calcium imaging approach coupled with cell labeling to examine how different taste modalities are processed in the fly brain. These studies reveal that sweet, bitter, and water sensory cells activate different cell populations throughout the subesophageal zone, with most cells responding to a single taste modality. Pathways for sweet and bitter tastes are segregated from sensory input to motor output and this segregation is maintained in higher brain areas, including regions implicated in learning and neuromodulation. Our work reveals independent processing of appetitive and aversive tastes, suggesting that flies and mammals use a similar coding strategy to ensure innate responses to salient compounds.
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