Aberrant somatosensory phase synchronization in children with hemiplegic cerebral palsy.
Aberrant somatosensory phase synchronization in children with hemiplegic cerebral palsy.
复制标题
偏瘫性脑瘫患儿体感相同步异常。
DOI：
10.1016/j.neulet.2021.136169
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发表时间：
2021-09-25
影响因子：
2.5
通讯作者：
Papadelis C
中科院分区：
文献类型：
--
作者：
Song Y;Renoul E;Acord S;Johnson YR;Marks W;Alexandrakis G;Papadelis C
患有偏瘫性脑瘫（HCP）的儿童经常表现出躯体感觉障碍。尽管有大量证据表明体感缺陷，但与 HCP 儿童体感缺陷相关的神经生理学改变尚未得到阐明。在这里，我们的目的是评估 HCP 儿童对侧初级 (S1) 和次级 (S2) 体感区域内部和之间的相位同步性。 S1 和 S2 内和之间的区域内和区域间相位同步是通过响应对侧上肢被动气动刺激的体感诱发场 (SEF) 来估计的，并通过儿科脑磁图 (MEG) 记录 HCP 儿童和典型发育 (TD) 儿童。我们发现 HCP 儿童的两个半球 S1 内以及 S1 和 S2 之间存在异常相位同步。具体而言，与受影响较大的 (MA) 半球和 TD 儿童的优势半球相比，受影响较小的 (LA) 半球在刺激开始约 120 毫秒后表现出相位同步减弱，而与 LA 半球和 TD 优势半球相比，MA 半球在约 100 毫秒后表现出增强的相位同步。我们的研究结果表明 HCP 儿童的两个半球的体感功能连接异常。
Children with hemiplegic cerebral palsy (HCP) often show disturbances of somatosensation. Despite extensive evidence of somatosensory deficits, neurophysiological alterations associated with somatosensory deficits in children with HCP have not been elucidated. Here, we aim to assess phase synchrony within and between contralateral primary (S1) and secondary (S2) somatosensory areas in children with HCP. Intra-regional and inter-regional phase synchronizations within and between S1 and S2 were estimated from somatosensory evoked fields (SEFs) in response to passive pneumatic stimulation of contralateral upper extremities and recorded with pediatric magnetoencephalography (MEG) in children with HCP and typically developing (TD) children. We found aberrant phase synchronizations within S1 and between S1 and S2 in both hemispheres in children with HCP. Specifically, the less-affected (LA) hemisphere demonstrated diminished phase synchronizations after the stimulus onset up to ~ 120ms compared to the more-affected (MA) hemisphere and the dominant hemisphere of TD children, while the MA hemisphere showed enhanced phase synchronizations after ~100ms compared to the LA hemisphere and the TD dominant hemisphere. Our findings indicates abnormal somatosensory functional connectivity in both hemispheres of children with HCP.
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