Maternal glomerular filtration rate in pregnancy and fetal size.
Maternal glomerular filtration rate in pregnancy and fetal size.
复制标题
DOI：
10.1371/journal.pone.0101897
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Longnecker MP
中科院分区：
文献类型：
--
作者：
Morken NH;Travlos GS;Wilson RE;Eggesbø M;Longnecker MP
妊娠期母体肾小球滤过率（GFR）与胎儿大小的关系需要更好地表征，因为它影响了正在进行的关于母体GFR在重要环境污染物研究中的混杂效应的争论。我们的目的是描述母亲GFR和婴儿出生体重之间的关联大小。分析了2003-2007年期间在挪威母亲和儿童队列（MoBa）中招募的953名选定妇女（470名患有先兆子痫的妇女和483名没有先兆子痫的妇女）的子队列。根据血浆肌酐估计孕中期的GFR。出生体重由挪威医学出生登记处确定。采用多变量线性回归评价妊娠中期母体GFR（通过Cockroft-Gault [GFR-CG]和肾脏疾病饮食改良[GFR-MDRD]配方估计）与婴儿出生体重之间的相关性。还计算了偏相关系数。在校正母体体重（kg）、先兆子痫和分娩时胎龄（天）的模型中，母体GFR-CG（β：0.73 g/ml/min，p = 0.04）和GFR-MDRD（β：0.83 g/ml/min，p =0.04）与婴儿出生体重相关。 两种配方奶粉的婴儿出生体重与GFR之间的偏相关系数均为0.07。虽然先兆子痫妇女的出生体重与GFR的相关性更强，但与无先兆子痫妇女的差异无统计学意义。这些数据支持妊娠期间GFR和婴儿出生体重之间的关联，并表明GFR可能混淆选定的流行病学关联。
The relationship of maternal glomerular filtration rate (GFR) in pregnancy to fetal size needs to be better characterized as it impacts an ongoing debate about confounding effect of maternal GFR in investigations of important environmental contaminants. We aimed to characterize the size of the association between maternal GFR and infant birth weight. A sub-cohort of 953 selected women (470 women with and 483 women without preeclampsia) in the Norwegian Mother and Child Cohort (MoBa), recruited during 2003–2007 were analyzed. GFR in the second trimester was estimated based on plasma creatinine. Birth weight was ascertained from the Medical Birth Registry of Norway. Multivariate linear regression was used to evaluate the association between maternal GFR in second trimester (estimated by the Cockroft-Gault [GFR-CG] and the modification of diet in renal disease [GFR-MDRD] formulas) and infant birth weight. Partial correlation coefficients were also calculated. Maternal GFR-CG (β: 0.73 g/ml/min, p = 0.04) and GFR-MDRD (β: 0.83 g/ml/min, p = 0.04) were associated with infant birth weight in models adjusted for maternal weight in kilograms, preeclampsia, and gestational age at delivery (days). Partial correlation coefficients for the association between infant birth weight and GFR were 0.07 for both formulas. Although the birth weight-GFR association was stronger among the women with preeclampsia, the difference from women without preeclampsia was not statistically significant. These data support an association between GFR during pregnancy and infant birth weight, and indicate that GFR may confound selected epidemiologic associations.
登录
查看更多内容
影响因子：
7.7
作者：
Clark, S;Youngman, LD;Collins, R
通讯作者：
Collins, R
影响因子：
13.6
作者：
Ronningen, Kjersti S.;Paltiel, Liv;Hoppin, Jane A.
通讯作者：
Hoppin, Jane A.
DOI：
10.1111/j.1471-0528.2007.01529.x
发表时间：
2008-01-01
影响因子：
5.8
作者：
Smith, M. C.;Moran, P.;Davison, J. M.
通讯作者：
Davison, J. M.
影响因子：
3.7
作者：
Chen MH;Ha EH;Wen TW;Su YN;Lien GW;Chen CY;Chen PC;Hsieh WS
通讯作者：
Hsieh WS
产前暴露于全氟辛酸和20岁时超重的风险：一项前瞻性队列研究。
影响因子：
10.4
作者：
Halldorsson TI;Rytter D;Haug LS;Bech BH;Danielsen I;Becher G;Henriksen TB;Olsen SF
通讯作者：
Olsen SF