Quantification of fractional flow reserve based on angiographic image data.
Quantification of fractional flow reserve based on angiographic image data.
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DOI：
10.1007/s10554-010-9767-0
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发表时间：
2012-01
影响因子：
2.1
通讯作者：
Molloi, Sabee
中科院分区：
文献类型：
--
作者：
Wong, Jerry T.;Le, Huy;Suh, William M.;Chalyan, David A.;Mehraien, Toufan;Kern, Morton J.;Kassab, Ghassan S.;Molloi, Sabee
冠状动脉造影能很好地显示冠状动脉，但在评估冠状动脉狭窄的临床意义方面存在局限性。部分血流储备（FFR）已被证明是可靠的识别狭窄负责诱导缺血。本研究的目的是验证一种利用血管造影图像数据量化FFR的技术。本研究对10只麻醉闭胸猪使用血管成形术球囊导管进行部分闭塞。基于血管造影的FFR是根据血管造影测量的冠状动脉血流量与动脉管腔容积的比值来计算的。基于压力的FFR是通过冠状动脉远端压力与主动脉压力之比来测量的。压力丝法测量FFR （FFRP）与血管造影容积法测量FFR （FFRV）线性相关，公式为：FFRP = 0.41 FFRV + 0.52 （p值< 0.001）。相关系数为0.85，估计标准误差为0.07。这是第一个提供血管造影方法量化猪FFR的研究。在常规心导管诊断过程中，血管造影FFR可以潜在地评估冠状动脉狭窄的生理严重程度，而无需使用压力线穿过狭窄。
Coronary angiography provides excellent visualization of coronary arteries, but has limitations in assessing the clinical significance of a coronary stenosis. Fractional flow reserve (FFR) has been shown to be reliable in discerning stenoses responsible for inducible ischemia. The purpose of this study is to validate a technique for FFR quantification using angiographic image data. The study was carried out on 10 anesthetized, closed-chest swine using angioplasty balloon catheters to produce partial occlusion. Angiography based FFR was calculated from an angiographically measured ratio of coronary blood flow to arterial lumen volume. Pressure-based FFR was measured from a ratio of distal coronary pressure to aortic pressure. Pressure-wire measurements of FFR (FFRP) correlated linearly with angiographic volume-derived measurements of FFR (FFRV) according to the equation: FFRP = 0.41 FFRV + 0.52 (P-value < 0.001). The correlation coefficient and standard error of estimate were 0.85 and 0.07, respectively. This is the first study to provide an angiographic method to quantify FFR in swine. Angiographic FFR can potentially provide an assessment of the physiological severity of a coronary stenosis during routine diagnostic cardiac catheterization without a need to cross a stenosis with a pressure-wire.
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影响因子：
3.8
作者：
HANGIANDREOU, NJ;FOLTS, JD;MISTRETTA, CA
通讯作者：
MISTRETTA, CA
影响因子：
20.1
作者：
MESSINA, LM;HANLEY, FL;HOFFMAN, JIE
通讯作者：
HOFFMAN, JIE
影响因子：
37.8
作者：
Molloi, S;Ersahin, A;Leung, CY
通讯作者：
Leung, CY
影响因子：
37.8
作者：
PANTELY, GA;LADLEY, HD;BRISTOW, JD
通讯作者：
BRISTOW, JD
影响因子：
37.8
作者：
Molloi, S;Kassab, GS;Zhou, YF
通讯作者：
Zhou, YF