Longitudinal association between changes in resting-state network connectivity and cognition trajectories: The moderation role of a healthy diet.
Longitudinal association between changes in resting-state network connectivity and cognition trajectories: The moderation role of a healthy diet.
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DOI：
10.3389/fnhum.2022.1043423
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
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健康饮食已被证明可以改变大脑结构和功能并提高认知能力，我们小组之前的研究表明，地中海饮食（MeDi）可以调节健康成年人横断面样本中网络间静息状态功能连接（rsFC）对认知功能的影响。目前的研究旨在扩展之前的工作，测试 MeDi 是否可以调节网络间和网络内 rsFC 的变化对平均 5 年认知表现变化的影响。在基线和 5 年随访中，124 名 20-80 岁的成年人接受了静息态功能磁共振成像，以测量 10 个预定义网络内部和之间的连接性，并完成了六项认知任务，以测量四种认知参考能力 (RA)：流体推理 (FLUID)、情景记忆、处理速度和注意力以及词汇量。根据食物频率调查问卷 (FFQ)，参与者被分为低、中和高 Medi 组。使用多变量线性回归来测试 MeDi、网络内和网络间 rsFC 的变化以及认知功能的变化之间的关系。结果表明，MeDi 组显着调节了网络间和网络内 rsFC 整体变化对记忆表现变化的影响。对个体网络的探索性分析表明，MeDi 和网络间 rsFC 之间的相互作用对几乎所有个体网络都很重要，而 MeDi 对网络内 rsFC 变化和记忆变化之间关系的调节作用仅限于特定功能网络的子集。这些发现表明，健康饮食可以通过减弱连接随时间变化的负面影响来保护认知功能。需要进一步的研究来了解 MeDi 在整个生命周期中发挥神经保护作用的机制。
Healthy diet has been shown to alter brain structure and function and improve cognitive performance, and prior work from our group showed that Mediterranean diet (MeDi) moderates the effect of between-network resting-state functional connectivity (rsFC) on cognitive function in a cross-sectional sample of healthy adults. The current study aimed to expand on this previous work by testing whether MeDi moderates the effects of changes in between- and within-network rsFC on changes in cognitive performance over an average of 5 years. At baseline and 5-year follow up, 124 adults aged 20–80 years underwent resting state fMRI to measure connectivity within and between 10 pre-defined networks, and completed six cognitive tasks to measure each of four cognitive reference abilities (RAs): fluid reasoning (FLUID), episodic memory, processing speed and attention, and vocabulary. Participants were categorized into low, moderate, and high MeDi groups based on food frequency questionnaires (FFQs). Multivariable linear regressions were used to test relationships between MeDi, change in within- and between-network rsFC, and change in cognitive function. Results showed that MeDi group significantly moderated the effects of change in overall between-network and within-network rsFC on change in memory performance. Exploratory analyses on individual networks revealed that interactions between MeDi and between-network rsFC were significant for nearly all individual networks, whereas the moderating effect of MeDi on the relationship between within-network rsFC change and memory change was limited to a subset of specific functional networks. These findings suggest healthy diet may protect cognitive function by attenuating the negative effects of changes in connectivity over time. Further research is warranted to understand the mechanisms by which MeDi exerts its neuroprotective effects over the lifespan.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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