Glucagon-like peptide-1 regulation of carbohydrate intake is differentially affected by obesogenic diets.
Glucagon-like peptide-1 regulation of carbohydrate intake is differentially affected by obesogenic diets.
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DOI：
10.1038/oby.2011.342
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发表时间：
2012-02
期刊：
影响因子：
6.9
通讯作者：
Hajnal, Andras
中科院分区：
文献类型：
--
作者：
Pritchett, Carolyn E.;Hajnal, Andras
胰促胰岛素激素胰高血糖素样肽-1 （GLP-1）通过作为一种无氧肠-脑信号参与食欲调节。在肥胖的人和动物中，GLP-1的餐后释放可以减弱。然而，尚不清楚不同脂肪和碳水化合物含量的致肥性饮食是否会对GLP-1反馈的有效性产生不同的影响。为了研究这一点，雄性spraguedawley大鼠被喂食标准（低脂肪）食物，或两种不同脂肪含量（45或60千卡%）的高能量食物中的一种，持续28周。在给予GLP-1受体激动剂Exendin-4（0、0.5、1、2、3µg/kg; s.c）后，在未被剥夺的大鼠中摄入蔗糖和果糖溶液（西方饮食中常见的两种糖）。Exendin-4剂量依赖性地减少了短期（2小时）蔗糖和果糖的摄入。尽管两种饮食都导致肥胖，但在喂食更多脂肪的大鼠中，这种效果明显减弱。这些发现表明，当作为零食提供时，碳水化合物的摄入可以由GLP-1调节，并表明饮食中的脂肪消耗，而不是额外的卡路里或肥胖，可能导致抑制碳水化合物摄入的GLP-1反馈受损。未来的研究需要调查这些观察结果与人类的相关性，并阐明潜在的机制。
The incretin hormone glucagon-like peptide-1 (GLP-1) has been implicated in the regulation of appetite by acting as an anorexigenic gut-brain signal. The postprandial release of GLP-1 can be blunted in obese humans and animals. However, it remains unknown whether obesogenic diets with varying fat and carbohydrate content may differentially influence the effectiveness of GLP-1 feedback. To investigate this, male Sprague-Dawley rats were fed a standard (low fat) chow diet, or one of two high-energy diets varying in fat content (45 or 60 kcal%) for 28 weeks. Intake of sucrose and fructose solutions, two commonly added sugars in the Western diet, was then tested in non-deprived rats following administration of the GLP-1 receptor agonist, Exendin-4 (0, 0.5, 1, 2, 3 µg/kg; s.c.). Exendin-4 dose-dependently reduced short (2-hr) sucrose and fructose intake. This effect was significantly attenuated in rats fed more dietary fat despite both diets resulting in obesity. These findings demonstrate that intake of carbohydrates when offered as treats can be regulated by GLP-1 and suggests that dietary fat consumption, rather than extra calories or obesity, may lead to impaired GLP-1 feedback to curb carbohydrate intake. Future studies are warranted to investigate relevance of these observations to human and to elucidate the underlying mechanisms.
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