Phonological processing is uniquely associated with neuro-metabolic concentration.
Phonological processing is uniquely associated with neuro-metabolic concentration.
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DOI：
10.1016/j.neuroimage.2012.10.092
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发表时间：
2013-02-15
期刊：
影响因子：
5.7
通讯作者：
Manis FR
中科院分区：
文献类型：
--
作者：
Bruno JL;Lu ZL;Manis FR
阅读是一个复杂的过程，涉及大脑区域分布网络的招募和协调。本研究试图建立一个方法论上合理的证据基础，将特定的阅读和语音技能与神经代谢浓度联系起来。对31名具有一定范围阅读和语音能力的年轻人进行了单体素质子磁共振波谱分析，以测量角回周围左半球区域的代谢物浓度。相关数据表明，语音解码和正常化胆碱浓度之间的显着负相关，以及一个显着的负相关的趋势之间的视觉词阅读和正常化胆碱浓度，表明这些措施的分数较低，与较高浓度的胆碱。回归分析表明，胆碱浓度占一个独特的比例的语音解码措施后，占年龄，认知能力和视觉字阅读技能的变化。这种模式的结果表明胆碱浓度和语音解码之间的负相关关系的一些特异性。据我们所知，这是第一个研究提供证据，胆碱浓度在角区可能与语音技能独立的其他阅读技能，一般认知能力，和年龄。这些结果可能对阅读障碍的研究和治疗具有重要意义，这种障碍与语音解码缺陷和角回异常有关。
Reading is a complex process involving recruitment and coordination of a distributed network of brain regions. The present study sought to establish a methodologically sound evidentiary base relating specific reading and phonological skills to neuro-metabolic concentration. Single voxel proton magnetic resonance spectroscopy was performed to measure metabolite concentration in a left hemisphere region around the angular gyrus for 31 young adults with a range of reading and phonological abilities. Correlation data demonstrated a significant negative association between phonological decoding and normalized choline concentration and as well as a trend toward a significant negative association between sight word reading and normalized choline concentration, indicating that lower scores on these measures are associated with higher concentrations of choline. Regression analyses indicated that choline concentration accounted for a unique proportion of variance in the phonological decoding measure after accounting for age, cognitive ability and sight word reading skill. This pattern of results suggests some specificity for the negative relationship between choline concentration and phonological decoding. To our knowledge, this is the first study to provide evidence that choline concentration in the angular region may be related to phonological skills independently of other reading skills, general cognitive ability, and age. These results may have important implications for the study and treatment of reading disability, a disorder which has been related to deficits in phonological decoding and abnormalities in the angular gyrus.
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影响因子：
3
作者：
Jung, Rex E.;Gasparovic, Charles;Chavez, Robert S.;Caprihan, Arvind;Barrow, Ranee;Yeo, Ronald A.
通讯作者：
Yeo, Ronald A.
影响因子：
14.5
作者：
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5.7
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通讯作者：
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作者：
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通讯作者：
DAMASIO, H
影响因子：
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作者：
Pugh, KR;Mencl, WE;Shaywitz, BA
通讯作者：
Shaywitz, BA