Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study.
Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study.
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DOI：
10.1289/ehp.1307562
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发表时间：
2014-08
影响因子：
10.4
通讯作者：
Lanphear BP
中科院分区：
文献类型：
--
作者：
Chen A;Yolton K;Rauch SA;Webster GM;Hornung R;Sjödin A;Dietrich KN;Lanphear BP
背景：多溴二苯醚 (PBDE) 是一种持久性化学品，在过去三十年中被广泛用作家具、地毯衬垫、汽车座椅和其他消费品中的阻燃剂。目的：我们在美国研究样本中检查了子宫内暴露于多溴联苯醚是否与儿童认知功能和行为相关。方法：在前瞻性出生队列中，我们测量了 2003 年至 2006 年期间 309 名妊娠 16 周妇女的 BDE-47 和其他 PBDE 同系物的母体血清浓度，并跟踪了俄亥俄州辛辛那提的孩子。我们使用贝利婴儿发育量表 II 测量了 1、2 和 3 岁时的认知和运动能力； 5岁时使用韦克斯勒学前和小学智力量表-III进行智力评估；每年使用儿童行为评估系统 2 评估 2-5 岁儿童的行为。我们使用线性混合模型或广义估计方程并调整潜在的混杂因素来估计这些结果与 log10 转换的 PBDE 浓度之间的关联。结果：母体血清中 BDE-47 的几何平均值（20.1 ng/g 脂质）与美国成人国家参考值相当。产前 BDE-47 与 1-3 岁时贝利心理或精神运动发育指数没有显着相关性，但产前 BDE-47 增加 10 倍与 5 岁时全量表智商下降 4.5 分（95% CI：–8.8，–0.1）和多动评分增加 3.3 分（95% CI：0.3，6.3）相关。结论：产前接触 PBDE 与儿童智商较低和多动评分较高相关。引文：Chen A、Yolton K、Rauch SA、Webster GM、Hornung R、Sjödin A、Dietrich KN、Lanphear BP。 2014。产前多溴二苯醚暴露和美国 5 岁儿童的神经发育：HOME 研究。环境健康视角 122：856–862； http://dx.doi.org/10.1289/ehp.1307562
Background: Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. Objective: We examined whether in utero exposure to PBDEs is associated with child cognitive function and behavior in a U.S. study sample. Methods: In a prospective birth cohort, we measured maternal serum concentrations of BDE-47 and other PBDE congeners in 309 women at 16 weeks of gestation during 2003–2006 and followed their children in Cincinnati, Ohio. We measured cognitive and motor abilities using the Bayley Scales of Infant Development-II at ages 1, 2, and 3 years; intelligence using the Wechsler Preschool and Primary Scale of Intelligence-III at age 5 years; and children’s behaviors using the Behavioral Assessment System for Children-2 annually at ages 2–5 years. We used linear mixed models or generalized estimating equations with adjustment for potential confounders to estimate associations between these outcomes and log10-transformed PBDE concentrations. Results: The geometric mean of BDE-47 in maternal serum (20.1 ng/g lipid) was comparable with U.S. adult national reference values. Prenatal BDE-47 was not significantly associated with Bayley Mental or Psychomotor Development Indices at 1–3 years, but a 10-fold increase in prenatal BDE-47 was associated with a 4.5-point decrease (95% CI: –8.8, –0.1) in Full-Scale IQ and a 3.3-point increase (95% CI: 0.3, 6.3) in the hyperactivity score at age 5 years. Conclusions: Prenatal exposure to PBDEs was associated with lower IQ and higher hyperactivity scores in children. Citation: Chen A, Yolton K, Rauch SA, Webster GM, Hornung R, Sjödin A, Dietrich KN, Lanphear BP. 2014. Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study. Environ Health Perspect 122:856–862; http://dx.doi.org/10.1289/ehp.1307562
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10.4
作者：
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通讯作者：
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