An embedded four-channel receive-only RF coil array for fMRI experiments of the somatosensory pathway in conscious awake marmosets.
An embedded four-channel receive-only RF coil array for fMRI experiments of the somatosensory pathway in conscious awake marmosets.
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DOI：
10.1002/nbm.2965
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发表时间：
2013-11
影响因子：
2.9
通讯作者：
Silva, Afonso C.
中科院分区：
文献类型：
--
作者：
Papoti, Daniel;Yen, Cecil Chern-Chyi;Mackel, Julie B.;Merkle, Hellmut;Silva, Afonso C.
功能磁共振成像（fMRI）已成为神经科学和脑认知研究的主要研究工具。普通绒猴（Callithrix jacchus）是一种在生物医学研究中越来越受关注的非人灵长类动物模型。然而，用于绒猴的商业MRI线圈通常不可用。目前的工作描述了一个4通道接收只有表面RF线圈阵列的设计和建设具有良好的信噪比（SNR），专门优化清醒的绒猴在体感刺激的fMRI实验。该阵列被设计为基于头盔的头部保护系统的一部分，用于防止扫描期间的运动。高信噪比是通过构建线圈阵列，使用薄而灵活的基板粘到约束头盔的内表面，以最大限度地减少阵列元件和体感皮层之间的距离。线圈元件之间的去耦是通过部分几何重叠，并通过将它们连接到自制的低输入阻抗前置放大器。在体内图像显示出良好的覆盖大脑皮层表面与高灵敏度的躯体感觉皮层附近。在约束头盔内嵌入线圈元件允许fMRI数据响应于体感刺激，以高灵敏度和再现性收集在有意识的，清醒的绒猴。
Functional Magnetic Resonance Imaging (fMRI) has established itself as the main research tool in neuroscience and brain cognitive research. The common marmoset (Callithrix jacchus) is a non-human primate model of increasing interest in biomedical research. However, commercial MRI coils for marmosets are not generally available. The present work describes the design and construction of a 4-channel receive-only surface RF coil array with excellent signal-to-noise ratio (SNR) specifically optimized for fMRI experiments in awake marmosets in response to somatosensory stimulation. The array was designed as part of a helmet-based head restraint system used to prevent motion during the scans. High SNR was obtained by building the coil array using a thin and flexible substrate glued to the inner surface of the restraint helmet, so as to minimize the distance between the array elements and the somatosensory cortex. Decoupling between coil elements was achieved by partial geometrical overlapping and by connecting them to home-built low input impedance preamplifiers. In vivo images show excellent coverage of the brain cortical surface with high sensitivity near the somatosensory cortex. Embedding the coil elements within the restraint helmet allowed fMRI data in response to somatosensory stimulation to be collected with high sensitivity and reproducibility in conscious, awake marmosets.
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影响因子：
3
作者：
Bock, Nicholas A.;Kocharyan, Ara;Liu, Junjie V.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
影响因子：
5.7
作者：
Janssens, T.;Keil, B.;Farivar, R.;McNab, J. A.;Polimeni, J. R.;Gerits, A.;Arsenault, J. T.;Wald, L. L.;Vanduffel, W.
通讯作者：
Vanduffel, W.
影响因子：
2.9
作者：
Febo, Marcelo;Shields, Jessica;Ferris, Craig F.;King, Jean A.
通讯作者：
King, Jean A.
影响因子：
5.7
作者：
Hikishima, K.;Quallo, M. M.;Okano, H.
通讯作者：
Okano, H.
DOI：
10.1111/j.1460-9568.2009.06812.x
发表时间：
2009-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Masamoto K;Fukuda M;Vazquez A;Kim SG
通讯作者：
Kim SG