Body mass index and mortality from all causes and major causes in Japanese: results of a pooled analysis of 7 large-scale cohort studies.
Body mass index and mortality from all causes and major causes in Japanese: results of a pooled analysis of 7 large-scale cohort studies.
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DOI：
10.2188/jea.je20100180
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发表时间：
2011
影响因子：
4.7
通讯作者：
Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
中科院分区：
文献类型：
--
作者：
Sasazuki S;Inoue M;Tsuji I;Sugawara Y;Tamakoshi A;Matsuo K;Wakai K;Nagata C;Tanaka K;Mizoue T;Tsugane S;Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
我们汇集了日本7个持续队列的数据，涉及353 422名成年人(162 092名男性和191 330名女性)，以量化身体质量指数(BMI)对总死亡率和特定原因(癌症、心脏病和脑血管疾病)死亡率的影响，并确定日本中老年人的最佳BMI范围。在平均12.5年的随访期间，发生了41260例死亡。在每项研究中，在控制了年龄、居住地、吸烟、饮酒、高血压、糖尿病病史和体力活动后，使用Cox比例风险模型来估计每种BMI类别的危险比(HR)。随机效应模型被用来获得总结措施。全因和癌症死亡率呈反向J-型关系(仅女性高BMI风险升高)，心脏病和脑血管疾病死亡率呈U型或J型关联。总死亡率：男性14~19岁为1.78，19~21岁为1.27，21~23岁为1.11，30~40岁为1.36；女性14~19岁为1.61，19~21岁为1.17，27~30岁为1.08，30~40岁为1.37。高体重指数(≥27)分别占男性和女性总死亡率的0.9%和1.5%。在中老年日本人中，观察到总死亡率和主要疾病原因死亡率最低的是体重指数在21至27公斤/平方米之间。
We pooled data from 7 ongoing cohorts in Japan involving 353 422 adults (162 092 men and 191 330 women) to quantify the effect of body mass index (BMI) on total and cause-specific (cancer, heart disease, and cerebrovascular disease) mortality and identify optimal BMI ranges for middle-aged and elderly Japanese. During a mean follow-up of 12.5 years, 41 260 deaths occurred. The Cox proportional hazards model was used to estimate hazard ratios (HRs) for each BMI category, after controlling for age, area of residence, smoking, drinking, history of hypertension, diabetes, and physical activity in each study. A random-effects model was used to obtain summary measures. A reverse-J pattern was seen for all-cause and cancer mortality (elevated risk only for high BMI in women) and a U- or J-shaped association was seen for heart disease and cerebrovascular disease mortality. For total mortality, as compared with a BMI of 23 to 25, the HR was 1.78 for 14 to 19, 1.27 for 19 to 21, 1.11 for 21 to 23, and 1.36 for 30 to 40 in men, and 1.61 for 14 to 19, 1.17 for 19 to 21, 1.08 for 27 to 30, and 1.37 for 30 to 40 in women. High BMI (≥27) accounted for 0.9% and 1.5% of total mortality in men and women, respectively. The lowest risk of total mortality and mortality from major causes of disease was observed for a BMI of 21 to 27 kg/m2 in middle-aged and elderly Japanese.
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影响因子：
5
作者：
Baik, I;Ascherio, A;Willett, WC
通讯作者：
Willett, WC
影响因子：
4.9
作者：
Nanri, A.;Mizoue, T.;Tsugane, S.
通讯作者：
Tsugane, S.
影响因子：
5
作者：
Ford, ES;Williamson, DF;Liu, SM
通讯作者：
Liu, SM
影响因子：
5
作者：
Mizoue, Tetsuya;Inoue, Manami;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
影响因子：
24.5
作者：
Inoue, M.;Sasazuki, S.;Tsugane, S.
通讯作者：
Tsugane, S.