The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing.
The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing.
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脂肪干细胞条件培养基对烧蚀点阵二氧化碳激光换肤后伤口愈合的影响
DOI：
10.1155/2013/519126
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发表时间：
2013
影响因子：
--
通讯作者：
Luo D
中科院分区：
文献类型：
--
作者：
Zhou BR;Xu Y;Guo SL;Xu Y;Wang Y;Zhu F;Permatasari F;Wu D;Yin ZQ;Luo D
Objective.评价脂肪干细胞条件培养液（ADSC-CM）对人皮肤分次二氧化碳激光表面置换术（FxCR）后创面愈合的作用。材料和方法。19例受试者在双侧内侧臂接受FxCR治疗。将ADSC-CM应用于随机选择的一只手臂的FxCR部位，测量两个手臂的经皮水分损失（TEWL）、皮肤颜色和FxCR部位的粗弹性。治疗3周后取3例受试者的皮肤标本进行组织病理学检查，并记录I型和III型前胶原、弹性蛋白基因的mRNA表达。结果ADSC-CM治疗皮肤的红斑、黑色素和TEWL指数显著低于对照侧。ADSC-CM治疗3周后，治疗组Ⅲ型前胶原mRNA的表达是对照组的2.6倍。结论应用同种异体移植物ADSC-CM是一种通过减少一过性不良反应（如红斑、色素沉着过度和TEWL增加）来促进FxCR后伤口愈合的有效方法。
Objective. To evaluate the benefits of conditioned medium of Adipose-derived stem cells (ADSC-CM) on wound healing after fractional carbon dioxide laser resurfacing (FxCR) on human skin. Materials and Methods. Nineteen subjects were treated with FxCR on the bilateral inner arms. ADSC-CM was applied on FxCR site of one randomly selected arm. Transepidermal water loss (TEWL), skin color, and gross-elasticity of FxCR site on both arms were measured. Skin samples were taken by biopsy from three subjects 3 weeks after treatment for histopathological manifestations and mRNA expressions of procollagen types I and III, elastin genes were noted. Results. The index of erythema, melanin, and TEWL of the ADSC-CM-treated skin were significantly lower than those of the control side. The mRNA expression of type III procollagen in ADSC-CM-treated group at 3 weeks posttreatment was 2.6 times of that of the control group. Conclusion. Application of allograft ADSC-CM is an effective method for enhancing wound healing after FxCR, by reducing transient adverse effects such as erythema, hyperpigmentation, and increased TEWL.
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影响因子：
4.6
作者：
Kim, Won-Serk;Park, Byung-Soon;Sung, Jong-Hyuk
通讯作者：
Sung, Jong-Hyuk
影响因子：
6.5
作者：
Chung, JH;Seo, JY;Eun, HC
通讯作者：
Eun, HC
影响因子：
4.1
作者：
Liu, Shiyu;Zhang, Hongmei;Jin, Yan
通讯作者：
Jin, Yan
影响因子：
2.4
作者：
Park, Byung-Soon;Jang, Kyoung Ae;Kim, Won-Serk
通讯作者：
Kim, Won-Serk
影响因子：
1.2
作者：
Park, Byung-Soon;Kim, Won-Serk;Fukuoka, Hirotaro
通讯作者：
Fukuoka, Hirotaro