Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice.
Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice.
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低剂量的壳聚糖补充剂可改善小鼠肠道通透性并损害屏障功能
DOI：
10.1155/2016/4847296
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发表时间：
2016
影响因子：
--
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Guan G;Wang H;Peng H;Li G
本研究旨在探讨低剂量壳聚糖（COS）对小鼠体重、摄食量、肠道屏障功能和通透性的影响。将20只小鼠随机分配至接受未掺杂的对照饮食（对照组）或饮食补充有30 mg/kg剂量的壳聚糖（COS组）两周。COS组小鼠血清D-乳酸含量显著升高（P <0.05），空肠二胺氧化酶（DAO）活性显著降低（P <0.05），而体重和饮水量无显著差异。COS组小鼠回肠组织中occludin和ZO-1的表达明显降低（P < 0.05），occludin的表达明显降低（P < 0.05）。从这些发现中得出的结论表明，虽然30 mg/kg添加COS的饮食对小鼠的体重或摄食量没有影响，但该剂量可能会损害肠屏障功能和渗透性。该研究将有助于指导COS补充剂。
The purpose of this study was to explore relationships between low dose dietary supplementation with chitosan (COS) and body weight, feed intake, intestinal barrier function, and permeability in mice. Twenty mice were randomly assigned to receive an unadulterated control diet (control group) or a dietary supplementation with 30 mg/kg dose of chitosan (COS group) for two weeks. Whilst no significant differences were found between the conditions for body weight or food and water intake, mice in the COS group had an increased serum D-lactate content (P < 0.05) and a decreased jejunal diamine oxidase (DAO) activity (P < 0.05). Furthermore, mice in COS group displayed a reduced expression of occludin and ZO-1 (P < 0.05) and a reduced expression of occludin in the ileum (P < 0.05). The conclusion drawn from these findings showed that although 30 mg/kg COS-supplemented diet had no effect on body weight or feed intake in mice, this dosage may compromise intestinal barrier function and permeability. This research will contribute to the guidance on COS supplements.
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影响因子：
10.8
作者：
Chae, SY;Jang, MK;Nah, JW
通讯作者：
Nah, JW
影响因子：
2.1
作者：
Tang, ZR;Yin, YL;Fan, MZ
通讯作者：
Fan, MZ
影响因子：
11.2
作者：
Biswas, Subrata;Chattopadhyay, Mainak;Saha, Malay Kumar
通讯作者：
Saha, Malay Kumar
日粮添加N-氨甲酰谷氨酸可增加断奶环江小型猪仔猪肠道氨基酸转运蛋白的表达
影响因子：
3.3
作者：
Yang, H. S.;Fu, D. Z.;Yin, Y. L.
通讯作者：
Yin, Y. L.
补充半乳甘露聚糖或壳聚糖对早期断奶仔猪细胞免疫和体液免疫的影响
DOI：
10.5713/ajas.2008.70408
发表时间：
2008-05-01
期刊：
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
影响因子：
--
作者：
Yin, Y. -L.;Tang, Z. R.;Kim, S. W.
通讯作者：
Kim, S. W.