Frequency of normative word associations in the speech of individuals at familial high-risk for schizophrenia.
Frequency of normative word associations in the speech of individuals at familial high-risk for schizophrenia.
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DOI：
10.1016/j.schres.2012.06.034
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发表时间：
2012-09
影响因子：
4.5
通讯作者：
DeLisi, L. E.
中科院分区：
文献类型：
--
作者：
Manschreck, T. C.;Merrill, A. M.;Jabbar, G.;Chun, J.;DeLisi, L. E.
关键词：
精神分裂症患者言语中的联想干扰了连贯性和可理解性，这是一种被称为松散联想的正式思维障碍的特征。我们以前曾提出，松散的联想可能是语义联想网络中的过度活跃导致的，导致关联词在语音中出现的频率增加。使用顺序文本中的计算机关联(CAST)软件来量化语音中此类关联的频率，我们报告了来自精神分裂症患者和具有分裂型特征的个人的语言样本中更频繁的规范关联。本研究通过研究那些与精神分裂症患者有相同基因的人(即精神分裂症先驱的一级亲属；HR)但没有疾病的人的规范关联，进一步检验了精神分裂症中的这种偏差。家族性高危参与者(n=22)和对照组(n=24)对主题统觉测验中的卡片进行口头回答。CAST分析显示，与对照组相比，HR在他们的语音中使用了更多的关联词。此外，规范词汇联想的频率与分裂类型的维度和总分呈正相关，这证实了过去关于分裂类型和多联想之间关系的研究。我们的结果表明，精神分裂症患者的语言障碍可能源于一种潜在的心理病理机制，即语义联想的过度活跃。
The intrusion of associations into speech in schizophrenia disrupts coherence and comprehensibility, a feature of formal thought disorder referred to as loosened associations. We have previously proposed that loosened associations may result from hyperactivity in semantic association networks, leading to an increased frequency of associated words appearing in speech. Using Computed Associations in Sequential Text (CAST) software to quantify the frequency of such associations in speech, we have reported more frequent normative associations in language samples from patients with schizophrenia and in individuals with schizotypal characteristics. The present study further examined this deviance in schizophrenia by studying normative associations in those who share genes with an individual with schizophrenia, (i.e. first-degree relatives of probands with schizophrenia; HR) but who do not have an illness. Familial high-risk participants (n = 22), and controls (n = 24) provided verbal responses to cards from the Thematic Apperception Test. CAST analysis revealed that HR used more associated words in their speech compared to controls. Furthermore, the frequency of normative word associations was positively correlated with dimensional and total scores of schizotypy derived from ratings of the Structured Interview for Schizotypy, which confirms past research showing a relationship between schizotypy and hyperassociations. Our results suggest that language disturbances in schizophrenia likely arise from an underlying psychopathological mechanism, hyperactivity of semantic associations.
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