Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands.
Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands.
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DOI：
10.1039/c7lc00525c
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发表时间：
2017-07-25
期刊：
影响因子：
6.1
通讯作者：
Rogers JA
中科院分区：
文献类型：
--
作者：
Choi J;Xue Y;Xia W;Ray TR;Reeder JT;Bandodkar AJ;Kang D;Xu S;Huang Y;Rogers JA
在活动期间，汗腺产生与渗透作用相关的压力，将液体驱至皮肤表面。这些压力的大小可以提供对生理健康、体力消耗强度、心理压力因素和/或其他感兴趣的信息的见解，但由于缺乏非侵入性测量手段，它们目前是未知的。本文介绍了一种薄而柔软的可穿戴微流体系统，该系统安装在皮肤表面，可以精确和常规地测量皮肤表面几乎任何位置的分泌汗腺（表面SPSG，或s-SPSG）产生的分泌性流体压力。这些平台包含一组排列的细胞，每个细胞包括一个皮肤开口，一个可以流过汗液的入口，一个具有独特破裂压力（BP）的毛细血管破裂阀（CBV），一个相应的微储层来接收汗液，以及一个通往周围环境的出口来释放背压。bp系统地跨越了生理学相关的范围。这组单元格被设计成任意两个单元格之间的BP差大于组合的不确定性。人体研究表明，在不同条件下，从身体的不同部位测量s-SPSG。健康年轻人的平均值在2.4至2.9千帕之间。剧烈运动时出汗产生的s-SPSGs比久坐不动时产生的s-SPSGs要高一些。在所有情况下，前臂和下背部分别倾向于产生最高和最低的s-SPSGs。我们介绍了一种皮肤上安装的微流体装置，用于测量皮肤表面汗腺的分泌压力。
During periods of activity, sweat glands produce pressures associated with osmotic effects to drive liquid to the surface of the skin. The magnitudes of these pressures may provide insights into physiological health, the intensity of physical exertion, psychological stress factors and/other information of interest, yet they are currently unknown due to absence of means for non-invasive measurement. This paper introduces a thin, soft wearable microfluidic system that mounts onto the surface of the skin to enable precise and routine measurements of secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands (surface SPSG, or s-SPSG) at nearly any location on the body. These platforms incorporate an arrayed collection of unit cells each of which includes an opening to the skin, an inlet through which sweat can flow, a capillary bursting valve (CBV) with a unique bursting pressure (BP), a corresponding microreservoir to receive sweat and an outlet to the surrounding ambient to allow release of backpressure. The BPs systematically span the physiologically relevant range. The set of unit cells is designed such that the BP difference between any two unit cells is greater than the combined uncertainty. Human studies demonstrate measurements of s-SPSG under different conditions, from various regions of the body. Average values in healthy young adults lie between 2.4 and 2.9 kPa. Sweat associated with vigorous exercise have s-SPSGs that are somewhat higher than those associated with sedentary activity. For all conditions, the forearm and lower back tend to yield the highest and lowest s-SPSGs, respectively. We introduce a skin-mounted microfluidic device for measuring the secretory pressure of sweat glands at the surface of the skin.
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影响因子：
17.1
作者：
Koh A;Kang D;Xue Y;Lee S;Pielak RM;Kim J;Hwang T;Min S;Banks A;Bastien P;Manco MC;Wang L;Ammann KR;Jang KI;Won P;Han S;Ghaffari R;Paik U;Slepian MJ;Balooch G;Huang Y;Rogers JA
通讯作者：
Rogers JA
影响因子：
6.1
作者：
Hou, Linlin;Hagen, Joshua;Heikenfeld, Jason
通讯作者：
Heikenfeld, Jason
影响因子：
13.6
作者：
Lee H;Song C;Hong YS;Kim M;Cho HR;Kang T;Shin K;Choi SH;Hyeon T;Kim DH
通讯作者：
Kim DH
影响因子：
10
作者：
Choi, Jungil;Kang, Daeshik;Rogers, John A.
通讯作者：
Rogers, John A.
DOI：
10.1088/0960-1317/18/6/067001
发表时间：
2008-06-01
影响因子：
2.3
作者：
Eddings, Mark A.;Johnson, Michael A.;Gale, Bruce K.
通讯作者：
Gale, Bruce K.