The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey.
The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey.
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DOI：
10.3390/nu15143147
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发表时间：
2023-07-14
期刊：
影响因子：
5.9
通讯作者：
Xiao, Lin
中科院分区：
文献类型：
--
作者：
Liu, Si;Wu, Mingyang;Wang, Yan;Xiang, Lu;Luo, Gang;Lin, Qian;Xiao, Lin
关键词：
背景：Klotho是一种与衰老相关的标志物，与许多疾病密切相关。越来越多的证据表明，饮食因素和生活习惯会影响血清Klotho水平。膳食纤维是健康饮食的关键组成部分，对人体血清Klotho水平的影响尚未完全阐明。目的：本研究的目的是探讨美国40-79岁人群膳食纤维摄入量与血清Klotho水平之间的关系。方法：本研究共纳入11，282名参与者，均来自2007年至2016年的国家健康与营养检查调查。膳食纤维摄入量由统一培训的访谈者使用24小时膳食回忆法进行评估。使用IBL International，Japan生产的市售ELISA试剂盒定量血清Klotho。采用多元线性回归模型分析膳食纤维摄入量与血清Klotho水平之间的关系。随后，使用限制性三次样条（RCS）模型进一步探索两者之间的非线性剂量-反应关系。结果如下：调整潜在混杂因素后，所有参与者膳食纤维摄入量每增加一个四分位数，血清Klotho水平就增加1.9%（95%置信区间[CI]：0.8%，3.0%）。将膳食纤维摄入量作为分类变量，发现膳食纤维摄入量最高四分位数的参与者的血清Klotho水平比最低四分位数的参与者高4.7%（95% CI：1.8%，7.6%）。RCS图描绘了膳食纤维摄入量和血清Klotho水平之间的非线性正相关。亚组分析显示，膳食纤维摄入量与血清Klotho水平之间的关系在老年人（百分比变化：7.0%; 95% CI：2.5%，11.7%）和超重和肥胖参与者（百分比变化：4.9%; 95% CI：1.5%，8.4%）中更为明显。结论：这项研究的结果表明，膳食纤维摄入量与参与者的血清Klotho水平显着相关。这一发现还有待于前瞻性研究的进一步证实。
Background: Klotho is an aging-related marker closely associated with a number of diseases. A growing body of evidence suggests that dietary factors and lifestyle habits can impact serum Klotho levels. The effect of dietary fiber, a key component of a healthy diet, on the body’s serum Klotho levels has not been fully elucidated. Objective: The aim of this study was to explore the relationship between dietary fiber intake and serum Klotho levels in people aged 40–79 years in the United States. Methods: A total of 11,282 participants were included in this study, all from the National Health and Nutrition Examination Survey from 2007 to 2016. Dietary fiber intake was assessed by uniformly trained interviewers using the 24 h dietary recall method. Serum Klotho was quantified using commercially available ELISA kits manufactured by IBL International, Japan. The relationship between dietary fiber intake and serum Klotho levels was analyzed using a multiple linear regression model. Subsequently, the non-linear dose–response relationship between the two was further explored using a restricted cubic spline (RCS) model. Results: After adjusting for potential confounders, serum Klotho levels increased by 1.9% (95% confidence interval [CI]: 0.8%, 3.0%) for each interquartile range increase in dietary fiber intake in all participants. Considering dietary fiber intake as a categorical variable, serum Klotho levels were found to be 4.7% higher in participants in the highest quartile of dietary fiber intake than in those in the lowest quartile (95% CI: 1.8%, 7.6%). RCS plots depicted a non-linear positive correlation between dietary fiber intake and serum Klotho levels. Subgroup analysis revealed that the relationship between dietary fiber intake and serum Klotho levels was more pronounced in older (percentage change: 7.0%; 95% CI: 2.5%, 11.7%) and overweight and obese participants (percentage change: 4.9%; 95% CI: 1.5%, 8.4%). Conclusions: The results of this study showed that dietary fiber intake was significantly associated with serum Klotho levels in participants. This finding is yet to be further confirmed by prospective studies.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
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作者：
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影响因子：
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通讯作者：
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影响因子：
5.9
作者：
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通讯作者：
Amaro-Gahete, Francisco J.
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影响因子：
5.1
作者：
Gao, Xiang;Li, Yuhong;Li, Rena
通讯作者：
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