Effective corticospinal excitability neuromodulation elicited by short-duration concurrent and synchronized associative cortical and neuromuscular stimulations
Effective corticospinal excitability neuromodulation elicited by short-duration concurrent and synchronized associative cortical and neuromuscular stimulations
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短时并发和同步关联皮质和神经肌肉刺激引起有效的皮质脊髓兴奋性神经调节
DOI：
10.1016/j.neulet.2022.136910
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发表时间：
2022
影响因子：
2.5
通讯作者：
Nakazawa Kimitaka
中科院分区：
文献类型：
--
作者：
Cao Na;Sasaki Atsushi;Yuasa Akiko;Popovic Milos R.;Milosevic Matija;Nakazawa Kimitaka
联合重复联合经颅磁刺激（rTMS）和神经肌肉电刺激（NMES）的中枢神经系统（CNS）兴奋性的神经调节的最佳参数还没有得到很好的理解。我们使用初级运动皮层rTMS和上肢NMES研究了短时间并发和同步联合刺激后皮质脊髓的兴奋性。以50 Hz的脉冲群传递间歇性θ脉冲群刺激（iTBS），并在192 s的过程中以5 Hz重复，作为已建立的皮质易化rTMS方案。在相同的192 s持续时间内应用NMES以激活桡侧腕伸肌。比较了四种干预措施：（1）具有并发和同步的50 Hz NMES的iTBS;（2）具有并发和同步的5 Hz NMES的iTBS;（3）具有并发和同步的41 Hz NMES的iTBS;（4）具有5 s延迟和同步的50 Hz NMES的iTBS。单脉冲运动诱发电位（MEP）的反应引起的经颅磁刺激的初级运动皮层和最大运动反应（Mmax）引起的桡神经刺激进行了比较之前和每次干预后30分钟。我们的研究结果表明，皮质脊髓兴奋性（MEP/Mmax）仅在iTBS和同时50 Hz NMES干预后才得到促进，但在完成干预后10分钟内反应恢复到基线水平。这一结果表明，短时间的并发和同步刺激可以有效地神经调节皮质脊髓兴奋性。因此，在同时刺激期间，可以使用同步的50 Hz激活频率来增强初级运动皮层网络和感觉运动外围电路的重复同步关联刺激。
Optimal parameters of combined repetitive associative transcranial magnetic stimulation (rTMS) and neuromuscular electrical stimulation (NMES) for neuromodulation of central nervous system (CNS) excitability are not well understood. We examined corticospinal excitability after short-duration concurrent and synchronized associative stimulation applied using primary motor cortex rTMS and upper-limb NMES. Intermittent theta burst stimulation (iTBS) was delivered with burst at 50 Hz and repeated at 5 Hz over the course of 192 s as an established cortical facilitation rTMS protocol. NMES was applied to activate the extensor carpi radialis muscle over the same 192 s duration. Four interventions were compared: (1) iTBS with concurrent and synchronized 50 Hz NMES; (2) iTBS with concurrent and synchronized 5 Hz NMES; (3) iTBS with concurrent and asynchronized 41 Hz NMES; (4) iTBS with 5 s delayed and synchronized 50 Hz NMES. Single-pulse motor evoked potential (MEP) responses elicited by transcranial magnetic stimulation of the primary motor cortex and maximum motor responses (Mmax) elicited by radial nerve stimulation were compared before and for 30 min after each intervention. Our results showed that corticospinal excitability (MEP/Mmax) was only facilitated after the iTBS and concurrent 50 Hz NMES intervention, but the responses returned to baseline within 10 min of completing the intervention. This result demonstrates that short-duration concurrent and synchronized stimulation could be applied to effectively neuromodulate corticospinal excitability. Therefore, repetitive synchronized associative stimulation of the primary motor cortical networks and sensorimotor peripheral circuits may be enhanced using synchronized 50 Hz frequency of activation during concurrent stimulation.
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影响因子：
2.9
作者：
Hendy AM;Chye L;Teo WP
通讯作者：
Teo WP
神经肌肉电刺激踝跖屈肌后短期抑制下肢多块肌肉的脊髓反射
影响因子：
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作者：
Milosevic Matija;Masugi Yohei;Obata Hiroki;Sasaki Atsushi;Popovic Milos R.;Nakazawa Kimitaka
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影响因子：
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通过运动诱发电位的实时反馈来训练自愿运动抑制。
影响因子：
2.5
作者：
Majid,DSAdnan;Lewis,Christina;Aron,AdamR
通讯作者：
Aron,AdamR
运动水平外周电刺激对健康参与者和患有神经系统疾病的参与者的皮质脊髓兴奋性和功能结果测量有什么影响？
DOI：
--
发表时间：
2017
期刊：
影响因子：
--
作者：
S. Jaberzadeh;D. Mezhov;M. Zoghi
通讯作者：
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