Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou.
Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou.
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DOI：
10.1016/j.biopsych.2018.02.008
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发表时间：
2018-06-01
影响因子：
10.6
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Der-Avakian A;Pizzagalli DA
快乐的丧失（临床上称为快感缺失）、其他与奖励相关的过程（例如奖励学习、动机和奖励评估）受损以及情感迟钝是几种情绪和其他精神疾病的特征。尽管针对这些疾病有许多治疗选择，但与奖励相关的损害仍然难以治疗，并且尽管其他症状得到缓解，但通常仍然存在。缺乏具有高度构建和预测有效性的奖励相关损伤和情感的动物模型是开发新疗法的主要障碍。本次审查将重点强调：1）开发可转化动物模型时要考虑的指南； 2）最近在人类和非人类动物中开发新的奖励相关评估的努力，这些评估已从一个物种翻译或反向翻译到另一个物种。本综述中描述的程序用于评估奖励学习、动机行为、奖励评估和情感等方面。在一些情况下，研究人员试图实现与现有跨物种任务中使用的并行参数尽可能相同的任务参数，目的是改善临床前药物发现结果向临床的转化。在这方面，Athina Markou 博士对奖励相关过程的转化动物模型的开发和使用的概念化产生了巨大影响。因此，这篇综述献给 Markou 博士以及她在整个职业生涯中为理解和治疗多种精神疾病中与奖励相关的障碍所做的不懈努力。
Loss of pleasure (clinically referred to as anhedonia), impairments in other reward-related processes such as reward learning, motivation, and reward valuation, and blunted affect characterize several mood and other psychiatric disorders. Despite the availability of many therapeutic options for these disorders, reward-related impairments remain challenging to treat and often persist despite alleviation of other symptoms. Lack of animal models of reward-related impairments and affect that have high construct and predictive validity is a key obstacle to developing novel treatments. This review will highlight: 1) guidelines to consider when developing translatable animal models; and 2) recent efforts to develop new reward-related assessments in humans and non-human animals that have been translated or back-translated from one species to another. The procedures described in this review are used to assess aspects of reward learning, motivated behavior, reward valuation, and affect. In several cases, researchers have attempted to implement task parameters that are as identical as possible to the parallel parameters used in existing cross-species tasks, with the goal of improving the translation of preclinical drug discovery findings to the clinic. In this regard, Dr. Athina Markou had great influence on conceptualizing the development and use of translational animal models of reward-related processes. Thus, this review is dedicated to Dr. Markou and her tireless efforts throughout her career to understand and treat reward-related impairments across several psychiatric disorders.
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影响因子：
1.9
作者：
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通讯作者：
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