Sex Differences in the Blood Oxygen Level-Dependent Signal to Placebo Analgesia and Nocebo Hyperalgesia in Experimental Pain: A Functional MRI Study.
Sex Differences in the Blood Oxygen Level-Dependent Signal to Placebo Analgesia and Nocebo Hyperalgesia in Experimental Pain: A Functional MRI Study.
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实验性疼痛中安慰剂镇痛和反安慰剂痛觉过敏的血氧水平依赖性信号的性别差异：一项功能性 MRI 研究
DOI：
10.3389/fnbeh.2021.657517
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发表时间：
2021
影响因子：
3
通讯作者：
Wu W
中科院分区：
文献类型：
--
作者：
Shi Y;Zhan H;Zeng Y;Huang S;Cai G;Yang J;Wu W
目的安慰剂和反安慰剂反应在科研和临床实践中广泛存在。越来越多的证据表明，安慰剂和反安慰剂反应存在性别差异。然而，有关这一问题的数据仍然不足。本研究探讨是否BOLD信号的两个反应，功能性磁共振成像（fMRI）测量，不同性别的条件下，等效的实验疼痛感知。方法31名健康志愿者（14名女性）在急性下腰痛（ALBP）模型中接受了两次fMRI扫描，一次在安慰剂干预期间，一次在反安慰剂干预期间，伪随机顺序。每次扫描后收集视觉模拟评分（VAS）数据。对不同性别的fMRI数据进行功能连接分析（FC）和行为相关分析（BCA）。结果男性和女性受试者在安慰剂和反安慰剂反应中的VAS评分差异有统计学意义。两组在安慰剂反应的疼痛相关网络中也显示FC减少，而在反安慰剂反应的疼痛相关网络中FC升高。然而，在安慰剂条件下，男性参与者显示腹内侧前额叶皮层，海马旁回（PHP）和后扣带回皮层（PCC）的FC增加，而女性参与者显示背外侧前额叶皮层，海马回（HP）和岛叶皮层（IC）的FC增加。在反安慰剂条件下，男性参与者在PCC和HP中表现出FC减少，而女性参与者在中扣带皮层，丘脑（THS）和HP中表现出FC减少。两组的BCA结果也不同。结论内源性阿片系统和奖赏回路在安慰剂反应的性别差异中起重要作用，焦虑及其继发反应可能是反安慰剂反应性别差异的原因。
Objective Placebo as well as nocebo responses are widely found in scientific research and clinical practice. Growing evidence suggests sex differences in placebo as well as nocebo responses. However, data concerning this question are still insufficient. This study examined whether the BOLD signals of two responses, as measured with functional MRI (fMRI), differ by sex under conditions of equivalent experimental pain perception. Method Thirty-one healthy volunteers (14 female) underwent two fMRI scans, once during a placebo intervention and once during a nocebo intervention, pseudorandomly ordered, in an acute lower back pain (ALBP) model. We collected visual analog scale (VAS) data after each scanning. fMRI data from different sex groups were subjected to functional connectivity (FC) analysis and behavioral correlation analysis (BCA). Results The results showed statistical differences in VAS scores between male and female participants, in both placebo and nocebo responses. Both groups also showed reduced FC in the pain-associated network of the placebo response and elevated FC in the pain-related network of the nocebo response. However, in the placebo condition, male participants displayed increased FC in the ventromedial prefrontal cortex, parahippocampal gyrus (PHP), and posterior cingulate cortex (PCC), while female participants showed increased FC in the dorsolateral prefrontal cortex, hippocampal gyrus (HP), and insular cortex (IC). In the nocebo condition, male participants showed decreased FC in the PCC and HP, while female participants displayed decreased FC in the mid-cingulate cortex, thalamus (THS), and HP. The BCA results of the two groups were also different. Conclusion We found that the endogenous opioid system and reward circuit play a key role in sex differences of placebo response and that anxiety and its secondary reactions may cause the sex differences of nocebo response.
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影响因子：
5.7
作者：
Andreano, Joseph M.;Cahill, Larry
通讯作者：
Cahill, Larry
实验性急性腰痛中脑网络对针灸刺激的反应：一项功能磁共振成像研究
DOI：
10.1155/2015/210120
发表时间：
2015
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Shi Y;Liu Z;Zhang S;Li Q;Guo S;Yang J;Wu W
通讯作者：
Wu W
影响因子：
1
作者：
Benedetti, Fabrizio
通讯作者：
Benedetti, Fabrizio
影响因子：
4
作者：
Skibicka, Karolina P.;Dickson, Suzanne L.
通讯作者：
Dickson, Suzanne L.
影响因子：
5.7
作者：
Freeman S;Yu R;Egorova N;Chen X;Kirsch I;Claggett B;Kaptchuk TJ;Gollub RL;Kong J
通讯作者：
Kong J