Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.
Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.
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DOI：
10.1016/j.mri.2015.04.005
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发表时间：
2015-09
影响因子：
2.5
通讯作者：
Driehuys, Bastiaan
中科院分区：
文献类型：
--
作者：
He, Mu;Robertson, Scott H.;Kaushik, S. Sivaram;Freeman, Matthew S.;Virgincar, Rohan S.;Davies, John;Stiles, Jane;Foster, William M.;McAdams, H. Page;Driehuys, Bastiaan
本研究的目的是评估超极化 129Xe 剂量对多切片梯度回波和各向同性 3D 径向采集通气 MRI 上图像信噪比 (SNR) 和通气缺陷显着性的影响。十名不吸烟的老年受试者（年龄 60.8 ± 7.9 岁）使用 GRE 和 3D 径向采集进行超极化 (HP) 129Xe 通气 MRI，每个测试均使用 71 ml（高）和 24 ml（低）剂量当量 (DE) 的完全极化、完全浓缩的 129Xe。对于所有图像，计算了 SNR 和通气缺陷百分比 (VDP)。通过将 SNR 除以体素体积和剂量获得的归一化 SNR (SNRn) 对于高 DE GRE 采集 (SNRn=1.9±0.8 ml-2) 高于低 DE GRE 扫描 (SNRn=0.8±0.2 ml-2)。径向采集的图像表现出更一致，但 SNRn 较低（高 DE：SNRn=0.5±0.1 ml-2，低 DE：SNRn=0.5±0.2 ml-2）。 VDP 在所有扫描中都无法区分。这些结果表明使用高 DE GRE 序列获取的图像提供了最高的 SNRn，这与文献中先前的报告一致。 3D 径向图像的 SNRn 较低，但在视觉显示、磁化动态监测和生理梯度可视化方面具有优势。通过在剂量当量形式下评估归一化 SNR，应该可以预测 129Xe 剂量要求并量化更高效的发射/接收线圈、场强和脉冲序列的好处。
The aim of this study was to evaluate the effect of hyperpolarized 129Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI. Ten non-smoking older subjects (ages 60.8 ± 7.9 years) underwent hyperpolarized (HP) 129Xe ventilation MRI using both GRE and 3D-radial acquisitions, each tested using a 71 ml (high) and 24 ml (low) dose equivalent (DE) of fully polarized, fully enriched 129Xe. For all images SNR and ventilation defect percentage (VDP) was calculated. Normalized SNR (SNRn), obtained by dividing SNR by voxel volume and dose was higher for high-DE GRE acquisitions (SNRn=1.9±0.8 ml-2) than low-DE GRE scans (SNRn=0.8±0.2 ml-2). Radially acquired images exhibited a more consistent, albeit lower SNRn (High-DE: SNRn=0.5±0.1 ml-2, low-DE: SNRn=0.5±0.2 ml-2). VDP was indistinguishable across all scans. These results suggest images acquired using the high-DE GRE sequence provided the highest SNRn, which was in agreement with previous reports in the literature. 3D-radial images had lower SNRn, but have advantages for visual display, monitoring magnetization dynamics, and visualizing physiological gradients. By evaluating normalized SNR in the context of dose-equivalent formalism, it should be possible to predict 129Xe dose requirements and quantify the benefits of more efficient transmit/receive coils, field strengths, and pulse sequences.
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DOI：
10.1073/pnas.1011912107
发表时间：
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影响因子：
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