White matter connectivity and Internet gaming disorder.
White matter connectivity and Internet gaming disorder.
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DOI：
10.1111/adb.12246
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发表时间：
2016-05
影响因子：
3.4
通讯作者：
Renshaw PF
中科院分区：
文献类型：
--
作者：
Jeong BS;Han DH;Kim SM;Lee SW;Renshaw PF
网络使用和在线游戏可刺激健康受试者和网络游戏障碍（IGD）受试者的皮质-边缘回路。我们假设，与健康对照组相比，IGD患者会观察到分数各向异性（FA）增加而径向弥散性（RD）降低，并且这些白质指数与临床变量相关，包括疾病持续时间和执行功能。我们筛选了181名男性患者，以招募大量（n = 58）无精神合并症的IGD受试者和26名男性健康对照受试者。采用3.0特斯拉磁共振成像扫描仪获取多张弥散加权图像。应用基于束的空间统计方法比较IGD与健康对照者弥散张量成像（DTI）指标的组间差异。IGD组小钳、右丘脑前辐射、右皮质脊髓束、右下纵束、右扣带至海马和右下额枕束（IFOF）内的FA值升高，小钳、右丘脑前辐射和IFOF内的RD值平行降低。此外，IGD患者病程与全脑白质纤维完整性FA值呈正相关，与全脑白质轴突密度弥散性RD值负相关。在没有精神疾病的IGD受试者中，我们的DTI结果表明，右侧额叶纤维束髓鞘形成增加（FA增加，RD值降低）可能是长时间玩游戏的结果。
Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subjects, and that these white matter indices would be associated with clinical variables including duration of illness and executive function. We screened 181 male patients in order to recruit a large number (n = 58) of IGD subjects without psychiatric co-morbidity as well as 26 male healthy comparison subjects. Multiple diffusion-weighted images were acquired using a 3.0 Tesla magnetic resonance imaging scanner. Tract-based spatial statistics was applied to compare group differences in diffusion tensor imaging (DTI) metrics between IGD and healthy comparison subjects. IGD subjects had increased FA values within forceps minor, right anterior thalamic radiation, right corticospinal tract, right inferior longitudinal fasciculus, right cingulum to hippocampus and right inferior fronto-occipital fasciculus (IFOF) as well as parallel decreases in RD value within forceps minor, right anterior thalamic radiation and IFOF relative to healthy control subjects. In addition, the duration of illness in IGD subjects was positively correlated with the FA values (integrity of white matter fibers) and negatively correlated with RD scores (diffusivity of axonal density) of whole brain white matter. In IGD subjects without psychiatric co-morbidity, our DTI results suggest that increased myelination (increased FA and decreased RD values) in right-sided frontal fiber tracts may be the result of extended game play.
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影响因子：
3.4
作者：
Brubaker CJ;Schmithorst VJ;Haynes EN;Dietrich KN;Egelhoff JC;Lindquist DM;Lanphear BP;Cecil KM
通讯作者：
Cecil KM
影响因子：
3.7
作者：
Chan, Philip A;Rabinowitz, Terry
通讯作者：
Rabinowitz, Terry
影响因子：
1.7
作者：
Hamilton LS;Levitt JG;O'Neill J;Alger JR;Luders E;Phillips OR;Caplan R;Toga AW;McCracken J;Narr KL
通讯作者：
Narr KL
影响因子：
4.8
作者：
Han DH;Lyoo IK;Renshaw PF
通讯作者：
Renshaw PF
影响因子：
4.8
作者：
Catani, Marco
通讯作者：
Catani, Marco