Oral fungal profiling and risk of nasopharyngeal carcinoma: a population-based case-control study.
Oral fungal profiling and risk of nasopharyngeal carcinoma: a population-based case-control study.
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DOI：
10.1016/j.ebiom.2023.104813
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发表时间：
2023-10
期刊：
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
口腔真菌菌群的生态失调与包括癌症在内的一些疾病有关。然而，口腔真菌群落在鼻咽癌（NPC）癌变过程中的作用尚未被研究。我们使用真菌内部转录间隔区（ITS）-2测序对476例未经治疗的鼻咽癌患者和537例基于人群的对照进行了口腔唾液真菌菌群特征分析。通过生物信息学和生物统计学分析评估口腔真菌菌群与鼻咽癌风险之间的关系。我们发现较低的真菌α多样性与NPC的几率增加相关[较低vs.较高：观察到的特征（调整后的比值比[OR] = 5.81，95%置信区间[CI] = 3.60-9.38）; Simpson多样性（1.53，1.03-2.29）; Shannon多样性（2.03，1.35-3.04）]。我们还观察到基于Bray-Curtis相异度的病例和对照之间的全球真菌群落模式的显著差异（P < 0.001）。携带口腔真菌物种，特别是酿酒酵母，热带念珠菌，长孢洛德酵母，白色念珠菌和梨镰刀菌，与NPC的几率显着增加，OR值范围为1.56至4.66。具有低真菌和低细菌α多样性的个体患NPC的风险显著升高。我们的研究结果表明，口腔真菌群落的生态失调，其特征是真菌群落多样性的丧失和几种真菌生物的过度生长，与NPC的风险大幅增加有关。这项工作由the、the、the和the资助。
Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated. We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spacer (ITS)-2 sequencing. The relationship between oral fungal mycobiome and the risk of NPC was assessed through bioinformatic and biostatistical analyses. We found that lower fungal alpha diversity was associated with an increased odds of NPC [lower vs. higher: observed features (adjusted odds ratio [OR] = 5.81, 95% confidence interval [CI] = 3.60–9.38); Simpson diversity (1.53, 1.03–2.29); Shannon diversity (2.03, 1.35–3.04)]. We also observed a significant difference in global fungal community patterns between cases and controls based on Bray–Curtis dissimilarity (P < 0.001). Carriage of oral fungal species, specifically, Saccharomyces cerevisiae, Candida tropicalis, Lodderomyces elongisporus, Candida albicans, and Fusarium poae, was associated with significantly higher odds of NPC, with ORs ranging from 1.56 to 4.66. Individuals with both low fungal and low bacterial alpha diversity had a profoundly elevated risk of NPC. Our results suggest that dysbiosis in the oral mycobiome, characterized by a loss of fungal community diversity and overgrowth of several fungal organisms, is associated with a substantially increased risk of NPC. This work was funded by the , the , the , and the .
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影响因子：
4.6
作者：
Kumpitsch C;Moissl-Eichinger C;Pock J;Thurnher D;Wolf A
通讯作者：
Wolf A
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5.7
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48
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24.5
作者：
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Yu, Jun
影响因子：
158.5
作者：
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