Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study.
Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study.
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DOI：
10.3390/nu13082520
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发表时间：
2021-07-23
期刊：
影响因子：
5.9
通讯作者：
Larson-Meyer DE
中科院分区：
文献类型：
--
作者：
Hlucny K;Alexander BM;Gerow K;Larson-Meyer DE
背景：美国人群的碘状况被认为是适当的，但亚群人群仍然面临缺碘的风险，个体碘状况的生物标记物尚未确定。这项研究的目的是确定提供已知数量的碘盐的3天滴定饮食是否反映在24小时尿碘浓度(UIC)、血清碘和甲状腺球蛋白(TG)中。方法：10名受试者(31.3±4.0岁，76.1±6.3 kg)完成了3次3天的碘滴定饮食(最低碘、美国推荐每日摄入量和3×每日摄入量)。在每种饮食后测定24小时尿免疫球蛋白、血清碘和甘油三酯。基线时完成24小时尿液免疫积分和碘特定食物频率问卷(FFQ)。结果：每克食盐平均增加19.3UICg/L，从最低水平到μ(P=0.001)，从RDA到3×RDA差异显著(p=0.04)。血清碘与3×RDA差异显著(p=0.006)，而TG对饮食无明显影响。基线尿碘浓度与牛奶碘摄入量(r=0.688，p=0.028)和鱼/海产品碘摄入量(r=0.646，p=0.043)相关。结论：2 4hUIC和血清碘水平可反映个体碘营养状况，可作为碘营养状况的生物标志物。
Background: The iodine status of the US population is considered adequate, but subpopulations remain at risk for iodine deficiency and a biomarker of individual iodine status has yet to be determined. The purpose of this study was to determine whether a 3 day titration diet, providing known quantities of iodized salt, is reflected in 24 h urinary iodine concentration (UIC), serum iodine, and thyroglobulin (Tg). Methods: A total of 10 participants (31.3 ± 4.0 years, 76.1 ± 6.3 kg) completed three, 3 day iodine titration diets (minimal iodine, US RDA, (United States Recommended Daily Allowance), and 3× RDA). The 24 h UIC, serum iodine, and Tg were measured following each diet. The 24 h UIC and an iodine-specific food frequency questionnaire (FFQ) were completed at baseline. Results: UIC increased an average of 19.3 μg/L for every gram of iodized salt consumed and was different from minimal to RDA (p = 0.001) and RDA to 3× RDA diets (p = 0.04). Serum iodine was different from RDA to 3× RDA (p = 0.006) whereas Tg was not responsive to diet. Baseline UIC was associated with iodine intake from milk (r = 0.688, p = 0.028) and fish/seafood (r = 0.646, p = 0.043). Conclusion: These results suggest that 24 h UIC and serum iodine may be reflective of individual iodine status and may serve as biomarkers of iodine status.
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影响因子：
5.9
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